Gene:
PRKCD
protein kinase C, delta

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA33763

Details

Cytogenetic Location: chr3 : p21.31 - p21.1
GP mRNA Boundary: chr3 : 53195223 - 53226733
GP Gene Boundary: chr3 : 53185223 - 53229733
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.
  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. Alpha-synuclein signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. Apoptotic cleavage of cellular proteins - (Reactome via Pathway Interaction Database)
  3. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  4. Endothelins - (Pathway Interaction Database NCI-Nature Curated)
  5. Hedgehog signaling events mediated by Gli proteins - (Pathway Interaction Database NCI-Nature Curated)
  6. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  7. IGF1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  8. IL6-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  9. LPA receptor mediated events - (Pathway Interaction Database NCI-Nature Curated)
  10. PDGFR-beta signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  11. Role of Calcineurin-dependent NFAT signaling in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  12. Syndecan-2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  13. Syndecan-4-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  14. Thromboxane A2 receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  15. Trk receptor signaling mediated by PI3K and PLC-gamma - (Pathway Interaction Database NCI-Nature Curated)
  16. Trk receptor signaling mediated by the MAPK pathway - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ADRB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCG1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCG2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
RAF1
No related diseases are available

Publications related to PRKCD: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science (New York, N.Y.). 2008. Walsh Tom, et al. PubMed

LinkOuts

Entrez Gene:
5580
OMIM:
176977
UCSC Genome Browser:
NM_006254
RefSeq RNA:
NM_006254
NM_212539
RefSeq Protein:
NP_006245
NP_997704
RefSeq DNA:
AC_000046
AC_000135
NC_000003
NT_022517
NW_001838877
NW_921651
UniProtKB:
KPCD_HUMAN (Q05655)
Ensembl:
ENSG00000163932
GenAtlas:
PRKCD
GeneCard:
PRKCD
MutDB:
PRKCD
ALFRED:
LO091995H
HuGE:
PRKCD
Comparative Toxicogenomics Database:
5580
ModBase:
Q05655
HumanCyc Gene:
HS08969
HGNC:
9399

Common Searches