Gene:
PRKCA
protein kinase C, alpha

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs16960228 1854+3730G>A, 30062979G>A, 494902G>A, 64788827G>A
G > A
Intronic
No VIP available CA VA
rs4791040 1854+2476T>C, 30061725T>C, 493648T>C, 64787573T>C
T > C
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA33759

Details

Cytogenetic Location: chr17 : q22 - q23.2
GP mRNA Boundary: chr17 : 64298926 - 64806862
GP Gene Boundary: chr17 : 64288926 - 64809862
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.
  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.
  1. Proton Pump Inhibitor Pathway, Pharmacodynamics
    Genes involved in the proton pump activation and trafficking.
  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. a6b1 and a6b4 Integrin signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. activation of pkc through g-protein coupled receptors - (BioCarta via Pathway Interaction Database)
  3. angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling - (BioCarta via Pathway Interaction Database)
  4. aspirin blocks signaling pathway involved in platelet activation - (BioCarta via Pathway Interaction Database)
  5. attenuation of gpcr signaling - (BioCarta via Pathway Interaction Database)
  6. bcr signaling pathway - (BioCarta via Pathway Interaction Database)
  7. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  8. cadmium induces dna synthesis and proliferation in macrophages - (BioCarta via Pathway Interaction Database)
  9. Canonical NF-kappaB pathway - (Pathway Interaction Database NCI-Nature Curated)
  10. cbl mediated ligand-induced downregulation of egf receptors pathway - (BioCarta via Pathway Interaction Database)
  11. ccr3 signaling in eosinophils - (BioCarta via Pathway Interaction Database)
  12. Downstream signaling in naïve CD8+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  13. effects of calcineurin in keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  14. egf signaling pathway - (BioCarta via Pathway Interaction Database)
  15. fmlp induced chemokine gene expression in hmc-1 cells - (BioCarta via Pathway Interaction Database)
  16. g-secretase mediated erbb4 signaling pathway - (BioCarta via Pathway Interaction Database)
  17. growth hormone signaling pathway - (BioCarta via Pathway Interaction Database)
  18. ionomycin and phorbal ester signaling pathway - (BioCarta via Pathway Interaction Database)
  19. keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  20. links between pyk2 and map kinases - (BioCarta via Pathway Interaction Database)
  21. nitric oxide signaling pathway - (BioCarta via Pathway Interaction Database)
  22. oxidative stress induced gene expression via nrf2 - (BioCarta via Pathway Interaction Database)
  23. pdgf signaling pathway - (BioCarta via Pathway Interaction Database)
  24. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  25. pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase - (BioCarta via Pathway Interaction Database)
  26. Ras signaling in the CD4+ TCR pathway - (Pathway Interaction Database NCI-Nature Curated)
  27. regulation of eif-4e and p70s6 kinase - (BioCarta via Pathway Interaction Database)
  28. Retinoic acid receptors-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  29. role of egf receptor transactivation by gpcrs in cardiac hypertrophy - (BioCarta via Pathway Interaction Database)
  30. role of mef2d in t-cell apoptosis - (BioCarta via Pathway Interaction Database)
  31. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  32. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
  33. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  34. Syndecan-4-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  35. t cell receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  36. TCR signaling in naïve CD4+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  37. TCR signaling in naïve CD8+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  38. telomeres telomerase cellular aging and immortality - (BioCarta via Pathway Interaction Database)
  39. thrombin signaling and protease-activated receptors - (BioCarta via Pathway Interaction Database)
  40. tpo signaling pathway - (BioCarta via Pathway Interaction Database)
  41. transcription factor creb and its extracellular signals - (BioCarta via Pathway Interaction Database)
  42. trka receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  43. vegf hypoxia and angiogenesis - (BioCarta via Pathway Interaction Database)
  44. VEGFR1 specific signals - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ADRB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCG1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCG2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
RAF1

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
hydrochlorothiazide
Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
diuretics
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Thiazides, plain

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Hypertension

Publications related to PRKCA: 6

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genomic Association Analysis of Common Variants Influencing Antihypertensive Response to Hydrochlorothiazide. Hypertension. 2013. Turner Stephen T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Predicting response to short-acting bronchodilator medication using Bayesian networks. Pharmacogenomics. 2009. Himes Blanca E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PRKCA: a positional candidate gene for body mass index and asthma. American journal of human genetics. 2009. Murphy Amy, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PRKCA and multiple sclerosis: association in two independent populations. PLoS genetics. 2006. Saarela Janna, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Parathyroid hormone: past and present. The Journal of endocrinology. 2005. Potts John T. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1. Cancer chemotherapy and pharmacology. 2003. Ali Shadan, et al. PubMed

LinkOuts

Entrez Gene:
5578
OMIM:
176960
UCSC Genome Browser:
NM_002737
RefSeq RNA:
NM_002737
RefSeq Protein:
NP_002728
RefSeq DNA:
AC_000060
AC_000149
NC_000017
NG_012206
NT_010783
NW_001838454
NW_926918
UniProtKB:
B5BU22_HUMAN (B5BU22)
KPCA_HUMAN (P17252)
Ensembl:
ENSG00000154229
GenAtlas:
PRKCA
GeneCard:
PRKCA
MutDB:
PRKCA
ALFRED:
LO010499X
HuGE:
PRKCA
Comparative Toxicogenomics Database:
5578
ModBase:
P17252
HumanCyc Gene:
HS07962
HGNC:
9393

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