Gene:
PRKACG
protein kinase, cAMP-dependent, catalytic, gamma

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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  PKACg
PharmGKB Accession Id: PA33750

Details

Cytogenetic Location: chr9 : q13 - q21.11
GP mRNA Boundary: chr9 : 71627445 - 71629039
GP Gene Boundary: chr9 : 71624445 - 71639039
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.

External Pathways

Links to non-PharmGKB pathways.

  1. actions of nitric oxide in the heart - (BioCarta via Pathway Interaction Database)
  2. activation of camp-dependent protein kinase pka - (BioCarta via Pathway Interaction Database)
  3. activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor - (BioCarta via Pathway Interaction Database)
  4. akap95 role in mitosis and chromosome dynamics - (BioCarta via Pathway Interaction Database)
  5. attenuation of gpcr signaling - (BioCarta via Pathway Interaction Database)
  6. chrebp regulation by carbohydrates and camp - (BioCarta via Pathway Interaction Database)
  7. cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway - (BioCarta via Pathway Interaction Database)
  8. gata3 participate in activating the th2 cytokine genes expression - (BioCarta via Pathway Interaction Database)
  9. how progesterone initiates the oocyte maturation - (BioCarta via Pathway Interaction Database)
  10. mcalpain and friends in cell motility - (BioCarta via Pathway Interaction Database)
  11. nitric oxide signaling pathway - (BioCarta via Pathway Interaction Database)
  12. phospholipase c-epsilon pathway - (BioCarta via Pathway Interaction Database)
  13. protein kinase a at the centrosome - (BioCarta via Pathway Interaction Database)
  14. regulation of bad phosphorylation - (BioCarta via Pathway Interaction Database)
  15. regulation of ck1/cdk5 by type 1 glutamate receptors - (BioCarta via Pathway Interaction Database)
  16. repression of pain sensation by the transcriptional regulator dream - (BioCarta via Pathway Interaction Database)
  17. rho-selective guanine exchange factor akap13 mediates stress fiber formation - (BioCarta via Pathway Interaction Database)
  18. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  19. stathmin and breast cancer resistance to antimicrotubule agents - (BioCarta via Pathway Interaction Database)
  20. transcription factor creb and its extracellular signals - (BioCarta via Pathway Interaction Database)
  21. transcription regulation by methyltransferase of carm1 - (BioCarta via Pathway Interaction Database)

Curated Information ?

No related diseases are available

Publications related to PRKACG: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Estimating coverage and power for genetic association studies using near-complete variation data. Nature genetics. 2008. Bhangale Tushar R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation. The Journal of allergy and clinical immunology. 2006. Johnson Malcolm. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Parathyroid hormone: past and present. The Journal of endocrinology. 2005. Potts John T. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. The Journal of biological chemistry. 2003. MacDonald Patrick E, et al. PubMed

LinkOuts

Entrez Gene:
5568
OMIM:
176893
UCSC Genome Browser:
NM_002732
RefSeq RNA:
NM_002732
RefSeq Protein:
NP_002723
MutDB:
PRKACG
ALFRED:
LO045591Y
HuGE:
PRKACG
ModBase:
P22612
HumanCyc Gene:
HS09176
HGNC:
9382

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