Gene:
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha

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PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  PKACa
PharmGKB Accession Id: PA33748

Details

Cytogenetic Location: chr19 : p13.12 - p13.12
GP mRNA Boundary: chr19 : 14202500 - 14228559
GP Gene Boundary: chr19 : 14199500 - 14238559
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.
  1. Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Representation of genes involved in nicotine effects in dopaminergic neurons.

External Pathways

Links to non-PharmGKB pathways.

  1. Aurora A signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. Calcium signaling in the CD4+ TCR pathway - (Pathway Interaction Database NCI-Nature Curated)
  3. Class I PI3K signaling events mediated by Akt - (Pathway Interaction Database NCI-Nature Curated)
  4. DARPP-32 events - (Reactome via Pathway Interaction Database)
  5. Hedgehog signaling events mediated by Gli proteins - (Pathway Interaction Database NCI-Nature Curated)
  6. Loss of Nlp from mitotic centrosomes - (Reactome via Pathway Interaction Database)
  7. Loss of proteins required for interphase microtubule organization from the centrosome - (Reactome via Pathway Interaction Database)
  8. LPA4-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  9. Paxillin-dependent events mediated by a4b1 - (Pathway Interaction Database NCI-Nature Curated)
  10. Recruitment of mitotic centrosome proteins and complexes - (Reactome via Pathway Interaction Database)
  11. Retinoic acid receptors-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  12. Role of Calcineurin-dependent NFAT signaling in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  13. Signaling events mediated by HDAC Class I - (Pathway Interaction Database NCI-Nature Curated)
  14. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  15. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
  16. Syndecan-1-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  17. Syndecan-2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  18. Thromboxane A2 receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  19. VEGFR1 specific signals - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

No related diseases are available

Publications related to PRKACA: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Estimating coverage and power for genetic association studies using near-complete variation data. Nature genetics. 2008. Bhangale Tushar R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation. The Journal of allergy and clinical immunology. 2006. Johnson Malcolm. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Parathyroid hormone: past and present. The Journal of endocrinology. 2005. Potts John T. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways. The Journal of biological chemistry. 2003. MacDonald Patrick E, et al. PubMed

LinkOuts

Entrez Gene:
5566
OMIM:
601639
UCSC Genome Browser:
NM_002730
RefSeq RNA:
NM_002730
NM_207518
RefSeq Protein:
NP_002721
NP_997401
RefSeq DNA:
AC_000062
AC_000151
NC_000019
NT_011295
NW_001838483
NW_927195
UniProtKB:
KAPCA_HUMAN (P17612)
Ensembl:
ENSG00000072062
GenAtlas:
PRKACA
GeneCard:
PRKACA
MutDB:
PRKACA
ALFRED:
LO218345X
HuGE:
PRKACA
Comparative Toxicogenomics Database:
5566
ModBase:
P17612
HumanCyc Gene:
HS01051
HGNC:
9380

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