Gene:
STAT3
signal transducer and activator of transcription 3 (acute-phase response factor)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs4796793 -1697, -1915C>G, -1937C>G, 3304C>G, 40542210G>C, 5' upstream of STAT3 -1697bp from exon1, 5816362G>C, G>C, STAT3:
G > C
5' Flanking
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  None
Alternate Symbols:  APRF
PharmGKB Accession Id: PA337

Details

Cytogenetic Location: chr17 : q21.31 - q21.2
GP mRNA Boundary: chr17 : 40465343 - 40540513
GP Gene Boundary: chr17 : 40462343 - 40550513
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.

External Pathways

Links to non-PharmGKB pathways.

  1. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  2. egf signaling pathway - (BioCarta via Pathway Interaction Database)
  3. erk1/erk2 mapk signaling pathway - (BioCarta via Pathway Interaction Database)
  4. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  5. il 6 signaling pathway - (BioCarta via Pathway Interaction Database)
  6. IL12 signaling mediated by STAT4 - (Pathway Interaction Database NCI-Nature Curated)
  7. IL12-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  8. IL2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  9. il22 soluble receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  10. IL23-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  11. IL27-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  12. IL6-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  13. Neurotrophic factor-mediated Trk receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  14. pdgf signaling pathway - (BioCarta via Pathway Interaction Database)
  15. role of erbb2 in signal transduction and oncology - (BioCarta via Pathway Interaction Database)
  16. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  17. Signaling events mediated by HDAC Class I - (Pathway Interaction Database NCI-Nature Curated)
  18. Signaling events mediated by PTP1B - (Pathway Interaction Database NCI-Nature Curated)
  19. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
  20. stat3 signaling pathway - (BioCarta via Pathway Interaction Database)
  21. tpo signaling pathway - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
interferons

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Carcinoma, Renal Cell

Publications related to STAT3: 12

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics as a risk mitigation strategy for chemotherapeutic cardiotoxicity. Pharmacogenomics. 2013. Jensen Brian C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis. Leukemia research. 2010. Valdez Benigno C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs. Oncogene. 2010. Ramakrishnan V, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Molecular and therapeutic potential and toxicity of valproic acid. Journal of biomedicine & biotechnology. 2010. Chateauvieux S├ębastien, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Altered gene expression in busulfan-resistant human myeloid leukemia. Leukemia research. 2008. Valdez Benigno C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response. Molecular psychiatry. 2008. Wong M-L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nature genetics. 2008. Barrett Jeffrey C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
STAT3 mutations in the hyper-IgE syndrome. The New England journal of medicine. 2007. Holland Steven M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007. Ito Noriyuki, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Polymorphisms in signal transducer and activator of transcription 3 and lung function in asthma. Respiratory research. 2005. Litonjua Augusto A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor receptor inhibitor, EKB-569, in tumor cells and normal human keratinocytes. Molecular cancer therapeutics. 2004. Nunes Maria, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of the JAK-STAT pathway in PDGF-stimulated proliferation of human airway smooth muscle cells. American journal of physiology. Lung cellular and molecular physiology. 2002. Simon Amy R, et al. PubMed

LinkOuts

UniProtKB:
STAT3_HUMAN (P40763)
Ensembl:
ENSG00000168610
GenAtlas:
STAT3
GeneCard:
STAT3
MutDB:
STAT3
ALFRED:
LO011189U
HuGE:
STAT3
Comparative Toxicogenomics Database:
6774
ModBase:
P40763
HumanCyc Gene:
HS09792
HGNC:
11364

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