Gene:
PPIB
peptidylprolyl isomerase B (cyclophilin B)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  CYPB; OI9
PharmGKB Accession Id: PA33580

Details

Cytogenetic Location: chr15 : q22.31 - q22.31
GP mRNA Boundary: chr15 : 64448014 - 64455354
GP Gene Boundary: chr15 : 64445014 - 64465354
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Syndecan-1-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)

Publications related to PPIB: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. The New England journal of medicine. 2010. Barnes Aileen M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS genetics. 2009. Choi Jae Won, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PPIB mutations cause severe osteogenesis imperfecta. American journal of human genetics. 2009. van Dijk Fleur S, et al. PubMed

LinkOuts

Entrez Gene:
5479
OMIM:
123841
259440
UCSC Genome Browser:
NM_000942
RefSeq RNA:
NM_000942
RefSeq Protein:
NP_000933
RefSeq DNA:
AC_000058
AC_000147
NC_000015
NG_012979
NT_010194
NW_001838218
NW_925884
UniProtKB:
PPIB_HUMAN (P23284)
Ensembl:
ENSG00000166794
GenAtlas:
PPIB
GeneCard:
PPIB
MutDB:
PPIB
ALFRED:
LO218331S
HuGE:
PPIB
Comparative Toxicogenomics Database:
5479
ModBase:
P23284
HumanCyc Gene:
HS09452
HGNC:
9255

Common Searches