Gene:
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  GRB1; p85; p85-ALPHA
PharmGKB Accession Id: PA33312

Details

Cytogenetic Location: chr5 : q13.1 - q13.1
GP mRNA Boundary: chr5 : 67511584 - 67597649
GP Gene Boundary: chr5 : 67501584 - 67600649
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
    Representation of anti-diabetic drugs repaglinide, nateglinide and sulfonylurea effects on insulin secretion in pancreatic cells.
  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.
  1. Sorafenib Pharmacodynamics
    Mechanism of action of sorafenib

External Pathways

Links to non-PharmGKB pathways.

  1. a6b1 and a6b4 Integrin signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. actions of nitric oxide in the heart - (BioCarta via Pathway Interaction Database)
  3. akt signaling pathway - (BioCarta via Pathway Interaction Database)
  4. Angiopoietin receptor Tie2-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  5. Atypical NF-kappaB pathway - (Pathway Interaction Database NCI-Nature Curated)
  6. b cell survival pathway - (BioCarta via Pathway Interaction Database)
  7. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  8. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  9. control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) - (BioCarta via Pathway Interaction Database)
  10. corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
  11. ctcf: first multivalent nuclear factor - (BioCarta via Pathway Interaction Database)
  12. cxcr4 signaling pathway - (BioCarta via Pathway Interaction Database)
  13. E-cadherin signaling events - (Pathway Interaction Database NCI-Nature Curated)
  14. E-cadherin signaling in keratinocytes - (Pathway Interaction Database NCI-Nature Curated)
  15. E-cadherin signaling in the nascent adherens junction - (Pathway Interaction Database NCI-Nature Curated)
  16. egf signaling pathway - (BioCarta via Pathway Interaction Database)
  17. EPHA2 forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  18. EPHB forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  19. Ephrin B reverse signaling - (Pathway Interaction Database NCI-Nature Curated)
  20. EPO signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  21. erk and pi-3 kinase are necessary for collagen binding in corneal epithelia - (BioCarta via Pathway Interaction Database)
  22. fc epsilon receptor i signaling in mast cells - (BioCarta via Pathway Interaction Database)
  23. FGF signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  24. Gab1 signalosome - (Reactome via Pathway Interaction Database)
  25. growth hormone signaling pathway - (BioCarta via Pathway Interaction Database)
  26. human cytomegalovirus and map kinase pathways - (BioCarta via Pathway Interaction Database)
  27. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  28. igf-1 signaling pathway - (BioCarta via Pathway Interaction Database)
  29. IGF1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  30. il-2 receptor beta chain in t cell activation - (BioCarta via Pathway Interaction Database)
  31. il-7 signal transduction - (BioCarta via Pathway Interaction Database)
  32. IL1-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  33. IL2 signaling events mediated by PI3K - (Pathway Interaction Database NCI-Nature Curated)
  34. IL2 signaling events mediated by STAT5 - (Pathway Interaction Database NCI-Nature Curated)
  35. IL2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  36. IL23-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  37. IL4-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  38. IL6-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  39. inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages - (BioCarta via Pathway Interaction Database)
  40. influence of ras and rho proteins on g1 to s transition - (BioCarta via Pathway Interaction Database)
  41. inhibition of cellular proliferation by gleevec - (BioCarta via Pathway Interaction Database)
  42. Insulin Pathway - (Pathway Interaction Database NCI-Nature Curated)
  43. insulin signaling pathway - (BioCarta via Pathway Interaction Database)
  44. Integrins in angiogenesis - (Pathway Interaction Database NCI-Nature Curated)
  45. LPA receptor mediated events - (Pathway Interaction Database NCI-Nature Curated)
  46. mtor signaling pathway - (BioCarta via Pathway Interaction Database)
  47. mTOR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  48. multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation - (BioCarta via Pathway Interaction Database)
  49. N-cadherin signaling events - (Pathway Interaction Database NCI-Nature Curated)
  50. Nectin adhesion pathway - (Pathway Interaction Database NCI-Nature Curated)
  51. nerve growth factor pathway (ngf) - (BioCarta via Pathway Interaction Database)
  52. Neurotrophic factor-mediated Trk receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  53. nfat and hypertrophy of the heart - (BioCarta via Pathway Interaction Database)
  54. Nongenotropic Androgen signaling - (Pathway Interaction Database NCI-Nature Curated)
  55. Osteopontin-mediated events - (Pathway Interaction Database NCI-Nature Curated)
  56. p75(NTR)-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  57. Paxillin-dependent events mediated by a4b1 - (Pathway Interaction Database NCI-Nature Curated)
  58. Paxillin-independent events mediated by a4b1 and a4b7 - (Pathway Interaction Database NCI-Nature Curated)
  59. pdgf signaling pathway - (BioCarta via Pathway Interaction Database)
  60. PDGFR-alpha signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  61. PDGFR-beta signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  62. phospholipase c signaling pathway - (BioCarta via Pathway Interaction Database)
  63. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  64. Plasma membrane estrogen receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  65. pten dependent cell cycle arrest and apoptosis - (BioCarta via Pathway Interaction Database)
  66. rac1 cell motility signaling pathway - (BioCarta via Pathway Interaction Database)
  67. ras signaling pathway - (BioCarta via Pathway Interaction Database)
  68. ras-independent pathway in nk cell-mediated cytotoxicity - (BioCarta via Pathway Interaction Database)
  69. Reelin signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  70. regulation of bad phosphorylation - (BioCarta via Pathway Interaction Database)
  71. regulation of eif-4e and p70s6 kinase - (BioCarta via Pathway Interaction Database)
  72. role of erbb2 in signal transduction and oncology - (BioCarta via Pathway Interaction Database)
  73. role of erk5 in neuronal survival pathway - (BioCarta via Pathway Interaction Database)
  74. role of nicotinic acetylcholine receptors in the regulation of apoptosis - (BioCarta via Pathway Interaction Database)
  75. role of pi3k subunit p85 in regulation of actin organization and cell migration - (BioCarta via Pathway Interaction Database)
  76. S1P2 pathway - (Pathway Interaction Database NCI-Nature Curated)
  77. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  78. Signaling events mediated by PTP1B - (Pathway Interaction Database NCI-Nature Curated)
  79. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
  80. Signaling events mediated by the Hedgehog family - (Pathway Interaction Database NCI-Nature Curated)
  81. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  82. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
  83. skeletal muscle hypertrophy is regulated via akt-mtor pathway - (BioCarta via Pathway Interaction Database)
  84. t cell receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  85. the co-stimulatory signal during t-cell activation - (BioCarta via Pathway Interaction Database)
  86. the igf-1 receptor and longevity - (BioCarta via Pathway Interaction Database)
  87. thrombin signaling and protease-activated receptors - (BioCarta via Pathway Interaction Database)
  88. tpo signaling pathway - (BioCarta via Pathway Interaction Database)
  89. transcription factor creb and its extracellular signals - (BioCarta via Pathway Interaction Database)
  90. trefoil factors initiate mucosal healing - (BioCarta via Pathway Interaction Database)
  91. Trk receptor signaling mediated by PI3K and PLC-gamma - (Pathway Interaction Database NCI-Nature Curated)
  92. trka receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  93. tumor suppressor arf inhibits ribosomal biogenesis - (BioCarta via Pathway Interaction Database)
  94. vegf hypoxia and angiogenesis - (BioCarta via Pathway Interaction Database)
  95. VEGFR1 specific signals - (Pathway Interaction Database NCI-Nature Curated)
  96. VEGFR3 signaling in lymphatic endothelium - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
AKT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
FLT1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
FLT4
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
KDR
No related diseases are available

Publications related to PIK3R1: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proceedings of the National Academy of Sciences of the United States of America. 2009. Mandelker Diana, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Structural comparisons of class I phosphoinositide 3-kinases. Nature reviews. Cancer. 2008. Amzel L Mario, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
An integrated genomic analysis of human glioblastoma multiforme. Science (New York, N.Y.). 2008. Parsons D Williams, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genomic landscapes of human breast and colorectal cancers. Science (New York, N.Y.). 2007. Wood Laura D, et al. PubMed

LinkOuts

UniProtKB:
P85A_HUMAN (P27986)
Ensembl:
ENSG00000145675
GenAtlas:
PIK3R1
GeneCard:
PIK3R1
MutDB:
PIK3R1
ALFRED:
LO016410M
HuGE:
PIK3R1
Comparative Toxicogenomics Database:
5295
ModBase:
P27986
HumanCyc Gene:
HS07270
HGNC:
8979

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