Gene:
PHKB
phosphorylase kinase, beta

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA33268

Details

Cytogenetic Location: chr16 : q12.1 - q13
GP mRNA Boundary: chr16 : 47495210 - 47735434
GP Gene Boundary: chr16 : 47485210 - 47738434
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Phosphorylase kinase activates glycogen phosphorylase - (Reactome via Pathway Interaction Database)

LinkOuts

Entrez Gene:
5257
OMIM:
172490
261750
UCSC Genome Browser:
NM_000293
RefSeq RNA:
NM_000293
NM_001031835
RefSeq Protein:
NP_000284
NP_001027005
RefSeq DNA:
AC_000059
AC_000148
NC_000016
NG_016598
NT_010498
NW_001838287
NW_926462
UniProtKB:
KPBB_HUMAN (Q93100)
Ensembl:
ENSG00000102893
GenAtlas:
PHKB
GeneCard:
PHKB
MutDB:
PHKB
ALFRED:
LO029001M
HuGE:
PHKB
Comparative Toxicogenomics Database:
5257
ModBase:
Q93100
HumanCyc Gene:
HS02424
HGNC:
8927

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