Gene:
OTX2
orthodenticle homeobox 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA32849

Details

Cytogenetic Location: chr14 : q22.3 - q22.3
GP mRNA Boundary: chr14 : 57267425 - 57277184
GP Gene Boundary: chr14 : 57264425 - 57287184
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

Entrez Gene:
5015
OMIM:
600037
610125
UCSC Genome Browser:
NM_021728
RefSeq RNA:
NM_021728
NM_172337
RefSeq Protein:
NP_068374
NP_758840
RefSeq DNA:
AC_000057
AC_000146
NC_000014
NG_008204
NT_026437
NW_001838111
NW_925561
UniProtKB:
OTX2_HUMAN (P32243)
Ensembl:
ENSG00000165588
GenAtlas:
OTX2
GeneCard:
OTX2
MutDB:
OTX2
ALFRED:
LO171638A
HuGE:
OTX2
Comparative Toxicogenomics Database:
5015
ModBase:
P32243
HumanCyc Gene:
HS09253
HGNC:
8522

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