Gene:
BDNF
brain-derived neurotrophic factor

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs10835210 -128-15437G>T, -21-15778G>T, -421-21G>T, -58-21G>T, 25-15778G>T, 27635910C>A, 27695910C>A, 4-15778G>T, 52696G>T, 585+15135C>A, 586-1214C>A, 586-2619C>A, 655-2619C>A, 655-934C>A, 67-15778G>T
C > A
Intronic
No VIP available CA VA
rs11030104 -128-4044T>C, -138-2698T>C, -21-4385T>C, 226-4385T>C, 25-4385T>C, 27624517A>G, 27684517A>G, 4-4385T>C, 585+3742A>G, 64089T>C, 654+3742A>G, 67-4385T>C
A > G
Intronic
No VIP available No Clinical Annotations available VA
rs11030118 -1356C>T, -1374C>T, -1481C>T, -2110C>T, -22+17995C>T, -22+18830C>T, -22+18913C>T, -22+19128C>T, -241C>T, -480C>T, -557C>T, -604C>T, -862C>T, -967C>T, 25543C>T, 27663063G>A, 27723063G>A, 3+19896C>T
G > A
5' Flanking
No VIP available No Clinical Annotations available VA
rs11030119 -22+12956C>T, -22+13791C>T, -22+13874C>T, -22+14089C>T, 20504C>T, 27668102G>A, 27728102G>A, 3+14857C>T
G > A
Intronic
No VIP available CA VA
rs1491850 27689725T>C, 27749725T>C
T > C
Not Available
No VIP available No Clinical Annotations available VA
rs1967554 -129+2152T>G, -22+21499T>G, -22+2152T>G, -22+2170T>G, -22+22334T>G, -22+22417T>G, -22+22632T>G, -22+2664T>G, -22+2969T>G, -22+3285T>G, -422+2959T>G, -59+2959T>G, 1120A>C, 1278A>C, 1877A>C, 24+1370T>G, 27659559A>C, 27719559A>C, 29047T>G, 3+23400T>G, 66+2959T>G
A > C
Intronic
No VIP available No Clinical Annotations available VA
rs2030324 -22+14143T>C, -22+14978T>C, -22+15061T>C, -22+15276T>C, 21691T>C, 27666915A>G, 27726915A>G, 3+16044T>C
A > G
Intronic
No VIP available CA VA
rs61888800 -1325C>A, -22+18780C>A, -22+19615C>A, -22+19698C>A, -22+19913C>A, -22+250C>A, -22+566C>A, -422+240C>A, -571C>A, -589C>A, -59+240C>A, -696C>A, -77C>A, 26328C>A, 27662278G>T, 27722278G>T, 3+20681C>A, 66+240C>A
G > T
Intronic
No VIP available CA VA
rs6265 196G>A, 220G>A, 241G>A, 27619916C>T, 27679916C>T, 283G>A, 434C>T, 442G>A, 503C>T, 68690G>A, BDNF:Val66Met, Val148Met, Val66Met, Val74Met, Val81Met, Val95Met
C > T
Missense
Val66Met
No VIP available No Clinical Annotations available VA
rs7103411 -128-19652G>A, -21-19993G>A, -421-4236G>A, -58-4236G>A, 1307+1439C>T, 25-19993G>A, 27640125C>T, 27700125C>T, 4-19993G>A, 48481G>A, 586-18900C>T, 67-19993G>A, 743+1439C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs7124442 *2326A>A, 27617041C>T, 27677041C>T, 306-2747C>T, 375-2747C>T, 71564A>A
C > T
3' UTR
No VIP available No Clinical Annotations available VA
rs7127507 -129+6827A>G, -22+26174A>G, -22+27009A>G, -22+27092A>G, -22+27307A>G, -22+6827A>G, -22+6845A>G, -22+7339A>G, -22+7644A>G, -22+7960A>G, -422+7634A>G, -59+7634A>G, 1342+2197T>C, 24+6045A>G, 27654884T>C, 27714884T>C, 3+28075A>G, 33722A>G, 586-4141T>C, 66+7634A>G, 744-4141T>C
T > C
Intronic
No VIP available CA VA
rs7934165 -22+10208C>T, -22+9075C>T, -22+9910C>T, -22+9993C>T, 16623C>T, 27671983G>A, 27731983G>A, 3+10976C>T
G > A
Intronic
No VIP available CA VA
rs962369 -22+6638A>C, -22+6638A>G, -22+6638A>T, -22+7473A>C, -22+7473A>G, -22+7473A>T, -22+7556A>C, -22+7556A>G, -22+7556A>T, -22+7771A>C, -22+7771A>G, -22+7771A>T, 14186A>C, 14186A>G, 14186A>T, 27674420T>A, 27674420T>C, 27674420T>G, 27734420T>A, 27734420T>C, 27734420T>G, 3+8539A>C, 3+8539A>G, 3+8539A>T
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs988748 -1923G>C, -22+16313G>C, -22+17148G>C, -22+17231G>C, -22+17446G>C, 23861G>C, 27664745C>G, 27724745C>G, 3+18214G>C
C > G
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  neurotrophin
Alternate Symbols:  None
PharmGKB Accession Id: PA31891

Details

Cytogenetic Location: unavailable
GP mRNA Boundary: chr11 : 27676440 - 27743605
GP Gene Boundary: chr11 : 27673440 - 27753605
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Neurotrophic factor-mediated Trk receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. p75(NTR)-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
antidepressants
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
antipsychotics

Curated Information ?

Publications related to BDNF: 40

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis. Pharmacogenomics. 2013. Haerian Batoul Sadat. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Fine Mapping and Identification of BMI Loci in African Americans. American journal of human genetics. 2013. Gong Jian, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study. American journal of epidemiology. 2013. Park Sungshim Lani, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression. Pharmacogenetics and genomics. 2013. Murphy Greer M, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of genetic variation in pharmacodynamic factors with methadone dose required for effective treatment of opioid addiction. Pharmacogenomics. 2013. Levran Orna, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Pharmacogenetics in major depression: a comprehensive meta-analysis. Progress in neuro-psychopharmacology & biological psychiatry. 2013. Niitsu Tomihisa, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia. Schizophrenia research. 2013. Zhang Jian-Ping, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of bipolar disorder. Pharmacogenomics. 2013. Severino Giovanni, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of clinical response to risperidone. Pharmacogenomics. 2013. Llerena Adrián, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
DRD3, but not BDNF, genotype affects treatment response to paroxetine in major depressive disorder: a preliminary study. Journal of clinical psychopharmacology. 2012. Tsuchimine Shoko, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of antidepressant drugs: current clinical practice and future directions. Pharmacogenomics. 2012. Narasimhan Sneha, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genetic Predictors of Weight Loss and Weight Regain After Intensive Lifestyle Modification, Metformin Treatment, or Standard Care in the Diabetes Prevention Program. Diabetes care. 2011. Delahanty Linda M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of BDNF and COMT genotypes with cognitive processing of anti-smoking PSAs. Genes, brain, and behavior. 2011. Falcone Mary, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetic testing to predict antipsychotic-induced weight gain: a systematic review. Pharmacogenomics. 2011. Risselada Arne J, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients. Progress in neuro-psychopharmacology & biological psychiatry. 2011. Yoshimura Reiji, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BDNF Val66Met genotype and 6-month remission rates in late-life depression. The pharmacogenomics journal. 2011. Taylor W D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. The pharmacogenomics journal. 2011. Gupta A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Pharmacogenetics of lithium response in bipolar disorder. Pharmacogenomics. 2010. McCarthy Michael J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions. The pharmacogenomics journal. 2010. Correia C T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of antidepressive treatment. European archives of psychiatry and clinical neuroscience. 2010. Zobel Astrid, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Brain-derived neurotrophic factor ( BDNF) gene: no major impact on antidepressant treatment response. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). 2010. Domschke Katharina, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A genetic variant BDNF polymorphism alters extinction learning in both mouse and human. Science (New York, N.Y.). 2010. Soliman Fatima, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients. Neuropsychobiology. 2010. Zou Yan-Feng, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of lithium long-term treatment: focus on initiation and adaptation mechanisms. Neuropsychobiology. 2010. Serretti Alessandro, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Archives of general psychiatry. 2009. Licinio Julio, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2009. Perroud Nader, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of antidepressant response: an update. Human genomics. 2009. Drago Antonio, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature genetics. 2009. Thorleifsson Gudmar, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients. Pharmacogenomics. 2008. Dmitrzak-Weglarz Monika, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BDNF gene: functional Val66Met polymorphism in mood disorders and schizophrenia. Pharmacogenomics. 2008. Rybakowski Janusz K. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The molecular neurobiology of depression. Nature. 2008. Krishnan Vaishnav, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Brain-derived neurotrophic factor and obesity in the WAGR syndrome. The New England journal of medicine. 2008. Han Joan C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
BDNF variability in opioid addicts and response to methadone treatment: preliminary findings. Genes, brain, and behavior. 2008. de Cid R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BDNF gene is a genetic risk factor for schizophrenia and is related to the chlorpromazine-induced extrapyramidal syndrome in the Chinese population. Pharmacogenetics and genomics. 2008. Xu Ming-Qing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The antidepressant fluoxetine restores plasticity in the adult visual cortex. Science (New York, N.Y.). 2008. Maya Vetencourt José Fernando, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. American journal of human genetics. 2008. Mill Jonathan, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (New York, N.Y.). 2006. Chen Zhe-Yu, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Risperidone-related weight gain: genetic and nongenetic predictors. Journal of clinical psychopharmacology. 2006. Lane Hsien-Yuan, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science (New York, N.Y.). 2006. Berton Olivier, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Candidate genes for antidepressant response to selective serotonin reuptake inhibitors. Neuropsychiatric disease and treatment. 2005. Lotrich Francis E, et al. PubMed