nucleophosmin (nucleolar phosphoprotein B23, numatrin)
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).
|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Names:||nucleolar phosphoprotein B23; nucleophosmin/nucleoplasmin family, member 1; numatrin|
|Alternate Symbols: ||B23; NPM|
|PharmGKB Accession Id:||PA31712|
|Cytogenetic Location:||chr5 : q35.1 - q35.1|
|GP mRNA Boundary†:||chr5 : 170814708 - 170837888|
|GP Gene Boundary†:||chr5 : 170804708 - 170840888|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.
Links to non-PharmGKB pathways.
Publications related to NPM1: 6
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- DG Dosing Guideline information is available
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||Association of ABCB1 polymorphisms with survival and in vitro cytotoxicty in de novo acute myeloid leukemia with normal karyotype. The pharmacogenomics journal. 2010. Gréen H, et al.|
||Pharmacogenomics in acute myeloid leukemia. Pharmacogenomics. 2009. Roumier Christophe, et al.|
||Recurring mutations found by sequencing an acute myeloid leukemia genome. The New England journal of medicine. 2009. Mardis Elaine R, et al.|
||Interaction of cyclooxygenase-2 variants and smoking in pancreatic cancer: a possible role of nucleophosmin. Gastroenterology. 2009. Zhao Dan, et al.|
||Population-specific genetic variants important in susceptibility to cytarabine arabinoside cytotoxicity. Blood. 2009. Hartford Christine M, et al.|
||Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. The New England journal of medicine. 2008. Schlenk Richard F, et al.|