Gene:
NOTCH1
notch 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  TAN1
Alternate Symbols:  None
PharmGKB Accession Id: PA31683

Details

Cytogenetic Location: chr9 : q34.3 - q34.3
GP mRNA Boundary: chr9 : 139388896 - 139440238
GP Gene Boundary: chr9 : 139385896 - 139450238
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Publications related to NOTCH1: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nature genetics. 2014. Knoechel Birgit, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics and cancer stem cells: a changing landscape?. Trends in pharmacological sciences. 2011. Crea Francesco, et al. PubMed

LinkOuts

Entrez Gene:
4851
OMIM:
109730
190198
UCSC Genome Browser:
NM_017617
RefSeq RNA:
NM_017617
RefSeq Protein:
NP_060087
RefSeq DNA:
AC_000052
AC_000141
NC_000009
NG_007458
NT_024000
NW_001839245
NW_924573
UniProtKB:
NOTC1_HUMAN (P46531)
Ensembl:
ENSG00000148400
GenAtlas:
NOTCH1
GeneCard:
NOTCH1
MutDB:
NOTCH1
ALFRED:
LO057309Y
HuGE:
NOTCH1
Comparative Toxicogenomics Database:
4851
ModBase:
P46531
HumanCyc Gene:
HS07525
HGNC:
7881

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