Gene:
NFKBIA
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  IKBA; IkappaBalpha; MAD-3
PharmGKB Accession Id: PA31601

Details

Cytogenetic Location: chr14 : q13.2 - q13.2
GP mRNA Boundary: chr14 : 35870716 - 35873960
GP Gene Boundary: chr14 : 35867716 - 35883960
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. acetylation and deacetylation of rela in nucleus - (BioCarta via Pathway Interaction Database)
  2. Atypical NF-kappaB pathway - (Pathway Interaction Database NCI-Nature Curated)
  3. Aurora A signaling - (Pathway Interaction Database NCI-Nature Curated)
  4. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  5. cadmium induces dna synthesis and proliferation in macrophages - (BioCarta via Pathway Interaction Database)
  6. Canonical NF-kappaB pathway - (Pathway Interaction Database NCI-Nature Curated)
  7. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  8. Downstream TCR signaling - (Reactome via Pathway Interaction Database)
  9. HIV-1 Nef: Negative effector of Fas and TNF-alpha - (Pathway Interaction Database NCI-Nature Curated)
  10. IL23-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  11. LPA receptor mediated events - (Pathway Interaction Database NCI-Nature Curated)
  12. mechanism of gene regulation by peroxisome proliferators via ppara - (BioCarta via Pathway Interaction Database)
  13. NF-kB is activated and signals survival - (Reactome via Pathway Interaction Database)
  14. nf-kb signaling pathway - (BioCarta via Pathway Interaction Database)
  15. Osteopontin-mediated events - (Pathway Interaction Database NCI-Nature Curated)
  16. Signaling events mediated by HDAC Class I - (Pathway Interaction Database NCI-Nature Curated)

Publications related to NFKBIA: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009. Reyes-Gibby Cielito C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2009. Chang Ellen T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genomic landscapes of human breast and colorectal cancers. Science (New York, N.Y.). 2007. Wood Laura D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

Entrez Gene:
4792
OMIM:
164008
612132
UCSC Genome Browser:
NM_020529
RefSeq RNA:
NM_020529
RefSeq Protein:
NP_065390
RefSeq DNA:
AC_000057
AC_000146
NC_000014
NG_007571
NT_026437
NW_001838110
NW_925539
UniProtKB:
IKBA_HUMAN (P25963)
Ensembl:
ENSG00000100906
GenAtlas:
NFKBIA
GeneCard:
NFKBIA
MutDB:
NFKBIA
ALFRED:
LO214759C
HuGE:
NFKBIA
Comparative Toxicogenomics Database:
4792
ModBase:
P25963
HumanCyc Gene:
HS02162
HGNC:
7797

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