Gene:
NCBP2
nuclear cap binding protein subunit 2, 20kDa

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  CBP20; Cbc2; NIP1
PharmGKB Accession Id: PA31462

Details

Cytogenetic Location: chr3 : q29 - q29
GP mRNA Boundary: chr3 : 196662273 - 196669464
GP Gene Boundary: chr3 : 196659273 - 196679464
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Abortive elongation of HIV-1 transcript in the absence of Tat - (Reactome via Pathway Interaction Database)
  2. Cleavage of Growing Transcript in the Termination Region - (Reactome via Pathway Interaction Database)
  3. Elongation of Intron-Containing Transcripts and co-transcriptional mRNA splicing - (Reactome via Pathway Interaction Database)
  4. Formation of HIV-1 elongation complex containing HIV-1 Tat - (Reactome via Pathway Interaction Database)
  5. Formation of RNA Pol II elongation complex - (Reactome via Pathway Interaction Database)
  6. Formation of the Early Elongation Complex - (Reactome via Pathway Interaction Database)
  7. Formation of the HIV-1 Early Elongation Complex - (Reactome via Pathway Interaction Database)
  8. mRNA 3'-end processing - (Reactome via Pathway Interaction Database)
  9. mRNA Capping - (Reactome via Pathway Interaction Database)
  10. mRNA Splicing - Major Pathway - (Reactome via Pathway Interaction Database)
  11. mRNA Splicing - Minor Pathway - (Reactome via Pathway Interaction Database)
  12. Processing of Capped Intron-Containing Pre-mRNA - (Reactome via Pathway Interaction Database)
  13. Processing of Intronless Pre-mRNAs - (Reactome via Pathway Interaction Database)
  14. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs - (Reactome via Pathway Interaction Database)
  15. SLBP independent Processing of Histone Pre-mRNAs - (Reactome via Pathway Interaction Database)
  16. snRNP Assembly - (Reactome via Pathway Interaction Database)
  17. Transport of Mature mRNA derived from an Intron-Containing Transcript - (Reactome via Pathway Interaction Database)
  18. Transport of Mature mRNA Derived from an Intronless Transcript - (Reactome via Pathway Interaction Database)
  19. Transport of the SLBP Dependant Mature mRNA - (Reactome via Pathway Interaction Database)
  20. Transport of the SLBP independent Mature mRNA - (Reactome via Pathway Interaction Database)
  21. Viral Messenger RNA Synthesis - (Reactome via Pathway Interaction Database)

Publications related to NCBP2: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

Entrez Gene:
22916
OMIM:
605133
UCSC Genome Browser:
NM_007362
RefSeq RNA:
NM_001042540
NM_007362
RefSeq Protein:
NP_001036005
NP_031388
RefSeq DNA:
AC_000046
AC_000135
NC_000003
NT_029928
NW_001838889
NW_921873
UniProtKB:
NCBP2_HUMAN (P52298)
Ensembl:
ENSG00000114503
GenAtlas:
NCBP2
GeneCard:
NCBP2
MutDB:
NCBP2
ALFRED:
LO248515Z
HuGE:
NCBP2
Comparative Toxicogenomics Database:
22916
ModBase:
P52298
HumanCyc Gene:
HS03775
HGNC:
7659

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