Gene:
MCM4
minichromosome maintenance complex component 4

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  CDC21
Alternate Symbols:  CDC54; MGC33310; P1-Cdc21; hCdc21
PharmGKB Accession Id: PA30694

Details

Cytogenetic Location: chr8 : q11.21 - q11.21
GP mRNA Boundary: chr8 : 48872763 - 48890720
GP Gene Boundary: chr8 : 48862763 - 48893720
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Publications related to MCM4: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Changes in the gene expression profile of gastric cancer cells in response to ibuprofen: a gene pathway analysis. The pharmacogenomics journal. 2010. Bonelli P, et al. PubMed

LinkOuts

Entrez Gene:
4173
OMIM:
602638
UCSC Genome Browser:
NM_005914
RefSeq RNA:
NM_005914
NM_182746
RefSeq Protein:
NP_005905
NP_877423
RefSeq DNA:
AC_000051
AC_000140
NC_000008
NT_008183
NW_001839132
NW_923929
UniProtKB:
B3KMX0_HUMAN (B3KMX0)
MCM4_HUMAN (P33991)
Ensembl:
ENSG00000104738
GenAtlas:
MCM4
GeneCard:
MCM4
MutDB:
MCM4
ALFRED:
LO166556D
HuGE:
MCM4
Comparative Toxicogenomics Database:
4173
ModBase:
P33991
HumanCyc Gene:
HS02611
HGNC:
6947

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