Gene:
MAP2K5
mitogen-activated protein kinase kinase 5

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  HsT17454; MAPKK5; MEK5
PharmGKB Accession Id: PA30590

Details

Cytogenetic Location: chr15 : q23 - q23
GP mRNA Boundary: chr15 : 67835021 - 68099455
GP Gene Boundary: chr15 : 67825021 - 68102455
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. mapkinase signaling pathway - (BioCarta via Pathway Interaction Database)
  2. role of erk5 in neuronal survival pathway - (BioCarta via Pathway Interaction Database)
  3. Signalling to ERK5 - (Reactome via Pathway Interaction Database)
  4. Trk receptor signaling mediated by the MAPK pathway - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

No related diseases are available

Publications related to MAP2K5: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nature genetics. 2007. Winkelmann Juliane, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 1997. Kroll J, et al. PubMed

LinkOuts

UniProtKB:
MP2K5_HUMAN (Q13163)
Ensembl:
ENSG00000137764
GenAtlas:
MAP2K5
GeneCard:
MAP2K5
MutDB:
MAP2K5
ALFRED:
LO036902U
HuGE:
MAP2K5
Comparative Toxicogenomics Database:
5607
ModBase:
Q13163
HumanCyc Gene:
HS06391
HGNC:
6845

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