Gene:
MAP2K1
mitogen-activated protein kinase kinase 1

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PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  PRKMK1
Alternate Symbols:  MAPKK1; MEK1
PharmGKB Accession Id: PA30584

Details

Cytogenetic Location: chr15 : q22.1 - q22.33
GP mRNA Boundary: chr15 : 66679211 - 66783882
GP Gene Boundary: chr15 : 66669211 - 66786882
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.
  1. Sorafenib Pharmacodynamics
    Mechanism of action of sorafenib
  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling - (BioCarta via Pathway Interaction Database)
  2. anthrax toxin mechanism of action - (BioCarta via Pathway Interaction Database)
  3. aspirin blocks signaling pathway involved in platelet activation - (BioCarta via Pathway Interaction Database)
  4. bcr signaling pathway - (BioCarta via Pathway Interaction Database)
  5. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  6. cadmium induces dna synthesis and proliferation in macrophages - (BioCarta via Pathway Interaction Database)
  7. calcium signaling by hbx of hepatitis b virus - (BioCarta via Pathway Interaction Database)
  8. ccr3 signaling in eosinophils - (BioCarta via Pathway Interaction Database)
  9. Cellular roles of Anthrax toxin - (Pathway Interaction Database NCI-Nature Curated)
  10. ceramide signaling pathway - (BioCarta via Pathway Interaction Database)
  11. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  12. Class IB PI3K non-lipid kinase events - (Pathway Interaction Database NCI-Nature Curated)
  13. egf signaling pathway - (BioCarta via Pathway Interaction Database)
  14. EPHB forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  15. erk and pi-3 kinase are necessary for collagen binding in corneal epithelia - (BioCarta via Pathway Interaction Database)
  16. ERK1 activation - (Reactome via Pathway Interaction Database)
  17. erk1/erk2 mapk signaling pathway - (BioCarta via Pathway Interaction Database)
  18. fc epsilon receptor i signaling in mast cells - (BioCarta via Pathway Interaction Database)
  19. fmlp induced chemokine gene expression in hmc-1 cells - (BioCarta via Pathway Interaction Database)
  20. FOXM1 transcription factor network - (Pathway Interaction Database NCI-Nature Curated)
  21. Hedgehog signaling events mediated by Gli proteins - (Pathway Interaction Database NCI-Nature Curated)
  22. human cytomegalovirus and map kinase pathways - (BioCarta via Pathway Interaction Database)
  23. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  24. igf-1 signaling pathway - (BioCarta via Pathway Interaction Database)
  25. il-2 receptor beta chain in t cell activation - (BioCarta via Pathway Interaction Database)
  26. influence of ras and rho proteins on g1 to s transition - (BioCarta via Pathway Interaction Database)
  27. inhibition of cellular proliferation by gleevec - (BioCarta via Pathway Interaction Database)
  28. keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  29. links between pyk2 and map kinases - (BioCarta via Pathway Interaction Database)
  30. map kinase inactivation of smrt corepressor - (BioCarta via Pathway Interaction Database)
  31. mapkinase signaling pathway - (BioCarta via Pathway Interaction Database)
  32. mcalpain and friends in cell motility - (BioCarta via Pathway Interaction Database)
  33. melanocyte development and pigmentation pathway - (BioCarta via Pathway Interaction Database)
  34. nerve growth factor pathway (ngf) - (BioCarta via Pathway Interaction Database)
  35. Neurotrophic factor-mediated Trk receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  36. pdgf signaling pathway - (BioCarta via Pathway Interaction Database)
  37. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  38. phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway - (BioCarta via Pathway Interaction Database)
  39. RAF phosphorylates MEK - (Reactome via Pathway Interaction Database)
  40. Ras signaling in the CD4+ TCR pathway - (Pathway Interaction Database NCI-Nature Curated)
  41. ras-independent pathway in nk cell-mediated cytotoxicity - (BioCarta via Pathway Interaction Database)
  42. regulation of splicing through sam68 - (BioCarta via Pathway Interaction Database)
  43. role of egf receptor transactivation by gpcrs in cardiac hypertrophy - (BioCarta via Pathway Interaction Database)
  44. role of erbb2 in signal transduction and oncology - (BioCarta via Pathway Interaction Database)
  45. role of erk5 in neuronal survival pathway - (BioCarta via Pathway Interaction Database)
  46. role of mal in rho-mediated activation of srf - (BioCarta via Pathway Interaction Database)
  47. role of ß-arrestins in the activation and targeting of map kinases - (BioCarta via Pathway Interaction Database)
  48. roles of ß arrestin dependent recruitment of src kinases in gpcr signaling - (BioCarta via Pathway Interaction Database)
  49. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  50. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
  51. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  52. sprouty regulation of tyrosine kinase signals - (BioCarta via Pathway Interaction Database)
  53. t cell receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  54. tgf beta signaling pathway - (BioCarta via Pathway Interaction Database)
  55. tpo signaling pathway - (BioCarta via Pathway Interaction Database)
  56. trefoil factors initiate mucosal healing - (BioCarta via Pathway Interaction Database)
  57. Trk receptor signaling mediated by the MAPK pathway - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Curated Information ?

Evidence Drug
No Dosing Guideline available DL No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
trametinib
No related diseases are available

Publications related to MAP2K1: 8

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs. Oncogene. 2010. Ramakrishnan V, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. American journal of human genetics. 2008. Mill Jonathan, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Nature genetics. 2007. Razzaque M Abdur, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. Blood. 2007. Tissing Wim J E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Science (New York, N.Y.). 2006. Rodriguez-Viciana Pablo, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of Raf in vascular protection from distinct apoptotic stimuli. Science (New York, N.Y.). 2003. Alavi Alireza, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. The Journal of clinical investigation. 2003. Tiede Imke, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 1997. Kroll J, et al. PubMed

LinkOuts

Entrez Gene:
5604
OMIM:
115150
176872
UCSC Genome Browser:
NM_002755
RefSeq RNA:
NM_002755
RefSeq Protein:
NP_002746
RefSeq DNA:
AC_000058
AC_000147
NC_000015
NG_008305
NT_010194
NW_001838218
NW_925884
UniProtKB:
A4QPA9_HUMAN (A4QPA9)
MP2K1_HUMAN (Q02750)
Ensembl:
ENSG00000169032
GenAtlas:
MAP2K1
GeneCard:
MAP2K1
MutDB:
MAP2K1
ALFRED:
LO006499C
HuGE:
MAP2K1
Comparative Toxicogenomics Database:
5604
ModBase:
Q02750
HumanCyc Gene:
HS09869
HGNC:
6840

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