Gene:
KPNA4
karyopherin alpha 4 (importin alpha 3)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  IPOA3; MGC12217; MGC26703; QIP1; SRP3
PharmGKB Accession Id: PA30188

Details

Cytogenetic Location: chr3 : q25.33 - q25.33
GP mRNA Boundary: chr3 : 160212783 - 160283376
GP Gene Boundary: chr3 : 160209783 - 160293376
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

Entrez Gene:
3840
OMIM:
602970
UCSC Genome Browser:
NM_002268
RefSeq RNA:
NM_002268
RefSeq Protein:
NP_002259
RefSeq DNA:
AC_000046
AC_000135
NC_000003
NT_005612
NW_001838884
NW_921807
UniProtKB:
IMA4_HUMAN (O00629)
Ensembl:
ENSG00000186432
GenAtlas:
KPNA4
GeneCard:
KPNA4
MutDB:
KPNA4
ALFRED:
LO124301L
HuGE:
KPNA4
Comparative Toxicogenomics Database:
3840
ModBase:
O00629
HumanCyc Gene:
HS07221
HGNC:
6397

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