Gene:
IL3
interleukin 3 (colony-stimulating factor, multiple)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  P-cell stimulating factor; hematopoietic growth factor; mast-cell growth factor; multilineage-colony-stimulating factor
Alternate Symbols:  IL-3; MCGF; MGC79398; MGC79399; MULTI-CSF
PharmGKB Accession Id: PA29830

Details

Cytogenetic Location: chr5 : q31.1 - q31.1
GP mRNA Boundary: chr5 : 131396347 - 131398896
GP Gene Boundary: chr5 : 131386347 - 131401896
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway - Transcription Regulation, Pharmacodynamics
    Model displaying genes which may be involved in the nuclear complex formed that regulates transcription in response to glucocorticoids.

External Pathways

Links to non-PharmGKB pathways.

  1. Calcineurin-regulated NFAT-dependent transcription in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  2. Calcium signaling in the CD4+ TCR pathway - (Pathway Interaction Database NCI-Nature Curated)
  3. il 3 signaling pathway - (BioCarta via Pathway Interaction Database)
  4. regulation of bad phosphorylation - (BioCarta via Pathway Interaction Database)

Publications related to IL3: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Regulation of IL 3 expression by glucocorticoids in cloned murine T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1985. Culpepper J A, et al. PubMed

LinkOuts

Entrez Gene:
3562
OMIM:
147740
UCSC Genome Browser:
NM_000588
RefSeq RNA:
NM_000588
RefSeq Protein:
NP_000579
RefSeq DNA:
AC_000048
AC_000137
NC_000005
NT_034772
NW_001838952
NW_922784
UniProtKB:
IL3_HUMAN (P08700)
Ensembl:
ENSG00000164399
GenAtlas:
IL3
GeneCard:
IL3
MutDB:
IL3
ALFRED:
LO177272A
HuGE:
IL3
Comparative Toxicogenomics Database:
3562
ModBase:
P08700
HumanCyc Gene:
HS09073
HGNC:
6011

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