Gene:
HSP90AA1
heat shock protein 90kDa alpha (cytosolic), class A member 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  FLJ31884; HSP90N; Hsp89; Hsp90
PharmGKB Accession Id: PA29519

Details

Cytogenetic Location: chr14 : q32.33 - q32.31
GP mRNA Boundary: chr14 : 102547075 - 102606086
GP Gene Boundary: chr14 : 102544075 - 102616086
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    Genes involved in mediating glucocorticoid effects at the tissue level in the CNS and in the peripheral tissues including heart, lung, vasculatrue and guts.

External Pathways

Links to non-PharmGKB pathways.

  1. actions of nitric oxide in the heart - (BioCarta via Pathway Interaction Database)
  2. ahr signal transduction pathway - (BioCarta via Pathway Interaction Database)
  3. akt signaling pathway - (BioCarta via Pathway Interaction Database)
  4. Class I PI3K signaling events - (Pathway Interaction Database NCI-Nature Curated)
  5. Class I PI3K signaling events mediated by Akt - (Pathway Interaction Database NCI-Nature Curated)
  6. corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
  7. eNOS activation - (Reactome via Pathway Interaction Database)
  8. hypoxia and p53 in the cardiovascular system - (BioCarta via Pathway Interaction Database)
  9. hypoxia-inducible factor in the cardivascular system - (BioCarta via Pathway Interaction Database)
  10. Hypoxic and oxygen homeostasis regulation of HIF-1-alpha - (Pathway Interaction Database NCI-Nature Curated)
  11. IL2 signaling events mediated by PI3K - (Pathway Interaction Database NCI-Nature Curated)
  12. Integrins in angiogenesis - (Pathway Interaction Database NCI-Nature Curated)
  13. ion channels and their functional role in vascular endothelium - (BioCarta via Pathway Interaction Database)
  14. Loss of Nlp from mitotic centrosomes - (Reactome via Pathway Interaction Database)
  15. Loss of proteins required for interphase microtubule organization from the centrosome - (Reactome via Pathway Interaction Database)
  16. mechanism of gene regulation by peroxisome proliferators via ppara - (BioCarta via Pathway Interaction Database)
  17. Recruitment of mitotic centrosome proteins and complexes - (Reactome via Pathway Interaction Database)
  18. Regulation of Androgen receptor activity - (Pathway Interaction Database NCI-Nature Curated)
  19. Regulation of glucocorticoid receptor - (Pathway Interaction Database NCI-Nature Curated)
  20. Regulation of Telomerase - (Pathway Interaction Database NCI-Nature Curated)
  21. Signaling events mediated by HDAC Class II - (Pathway Interaction Database NCI-Nature Curated)
  22. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  23. tumor suppressor arf inhibits ribosomal biogenesis - (BioCarta via Pathway Interaction Database)
  24. vegf hypoxia and angiogenesis - (BioCarta via Pathway Interaction Database)
  25. VEGFR1 specific signals - (Pathway Interaction Database NCI-Nature Curated)

Publications related to HSP90AA1: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Evolving novel anti-HER2 strategies. The lancet oncology. 2009. Jones Kellie L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Altered gene expression in busulfan-resistant human myeloid leukemia. Leukemia research. 2008. Valdez Benigno C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells. The Journal of pharmacology and experimental therapeutics. 2006. Dey Aparajita, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Heat shock proteins' mRNA expression in asthma. Respirology (Carlton, Vic.). 2000. Tong W, et al. PubMed

LinkOuts

Entrez Gene:
3320
OMIM:
140571
UCSC Genome Browser:
NM_005348
RefSeq RNA:
NM_001017963
NM_005348
RefSeq Protein:
NP_001017963
NP_005339
RefSeq DNA:
AC_000057
AC_000146
NC_000014
NT_026437
NW_001838115
NW_925561
HuGE:
HSP90AA1
Comparative Toxicogenomics Database:
3320
ModBase:
P07900
HumanCyc Gene:
HS01372
HGNC:
5253

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