Gene:
HSPA1A
heat shock 70kDa protein 1A

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all HSPA1A variant annotations

Variant?
(142)
Alternate Names ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs1043620 -1103A>G, 222T>C, 3069342C>C, 3077402C>C, 3098516C>C, 31723755T>C, 31783755T>C, 3293335C>C, 4081A>G, Ile74=
C > T
5' Flanking
Ile74Ile
No VIP available CA VA
rs2227956 1478C>T, 3063859G>A, 3071920A>A, 3093033A>A, 31718272G>A, 31778272G>A, 3287853A>A, 9564C>T, Thr493Met
A > G
Missense
Thr493Met
No VIP available No Clinical Annotations available VA
rs506770 1695G>C, 2608C>G, 3070815G>C, 3078875C>C, 3099989C>C, 31725228G>C, 31785228G>C, 3294808C>C, Ala565=
C > G
Synonymous
Ala565Ala
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 142

Overview

Alternate Names:  HSPA1
Alternate Symbols:  HSP70-1
PharmGKB Accession Id: PA29498

Details

Cytogenetic Location: chr6 : p21.33 - p21.33
GP mRNA Boundary: chr6 : 31783291 - 31785719
GP Gene Boundary: chr6 : 31773291 - 31788719
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. chaperones modulate interferon signaling pathway - (BioCarta via Pathway Interaction Database)
  2. FOXM1 transcription factor network - (Pathway Interaction Database NCI-Nature Curated)
  3. hypoxia and p53 in the cardiovascular system - (BioCarta via Pathway Interaction Database)
  4. tumor suppressor arf inhibits ribosomal biogenesis - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
carbamazepine

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Epilepsy

Publications related to HSPA1A: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Interaction networks of lithium and valproate molecular targets reveal a striking enrichment of apoptosis functional clusters and neurotrophin signaling. The pharmacogenomics journal. 2011. Gupta A, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenetics and genomics. 2006. Alfirevic Ana, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood. 2003. Ross Mary E, et al. PubMed