Gene:
HSD11B1
hydroxysteroid (11-beta) dehydrogenase 1

PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.

PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.

PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.

Overview

Alternate Names:  11-beta-hydroxysteroid dehydrogenase 1; OTTHUMP00000034649; OTTHUMP00000034650; corticosteroid 11-beta-dehydrogenase isozyme 1; short chain dehydrogenase/reductase family 26C, member 1
Alternate Symbols:  11-DH; 11-beta-HSD1; HDL; HSD11; HSD11B; HSD11L; MGC13539; SDR26C1
PharmGKB Accession Id: PA29476

Details

Cytogenetic Location: chr1 : q32.2 - q32.2
GP mRNA Boundary†: chr1 : 209859550 - 209908295
GP Gene Boundary†: chr1 : 209849550 - 209911295
Strand: plus
Product Name: No data available
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Glucocorticoid biosynthesis - (Reactome via Pathway Interaction Database)
  2. visceral fat deposits and the metabolic syndrome - (BioCarta via Pathway Interaction Database)

Publications related to HSD11B1: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of glucocorticoid replacement could optimize the treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Clinics (São Paulo, Brazil). 2011. Moreira Ricardo P P, et al. [Article:21915484@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
11beta-hydroxysteroid dehydrogenase types 1 and 2: an important pharmacokinetic determinant for the activity of synthetic mineralo- and glucocorticoids. The Journal of clinical endocrinology and metabolism. 2002. Diederich Sven, et al. [Article:12466373@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Conversion of cortisone to cortisol and prednisone to prednisolone. British medical journal. 1967. Jenkins J S, et al. [Article:6023103@PubMed]

LinkOuts

Entrez Gene:
3290
OMIM:
600713
604931
UCSC Genome Browser:
NM_005525
RefSeq RNA:
NM_005525
NM_181755
RefSeq Protein:
NP_005516
NP_861420
RefSeq DNA:
AC_000044
AC_000133
NC_000001
NG_012081
NT_167186
NW_001838537
NW_926794
UniProtKB:
DHI1_HUMAN (P28845)
Ensembl:
ENSG00000117594
GenAtlas:
HSD11B1
GeneCard:
GC01P209859 (3290)
MutDB:
HSD11B1
ALFRED:
LO016830S
HuGE:
HSD11B1
Comparative Toxicogenomics Database:
3290
ModBase:
P28845
HumanCyc Gene:
HS04154
HGNC:
5208

Common Searches

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