Gene:
H19
H19, imprinted maternally expressed transcript (non-protein coding)

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PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  long intergenic non-protein coding RNA 8; non-protein coding RNA 8
Alternate Symbols:  ASM; ASM1; D11S813E; LINC00008; NCRNA00008
PharmGKB Accession Id: PA29091

Details

Cytogenetic Location: chr11 : p15.5 - p15.5
GP mRNA Boundary: chr11 : 2016406 - 2019065
GP Gene Boundary: chr11 : 2013406 - 2029065
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Hypertension

Publications related to H19: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Hypomethylation of the H19 gene causes not only Silver-Russell syndrome (SRS) but also isolated asymmetry or an SRS-like phenotype. American journal of human genetics. 2006. Bliek Jet, et al. PubMed

LinkOuts

Entrez Gene:
283120
OMIM:
103280
130650
180860
194071
UCSC Genome Browser:
NM_032774
RefSeq RNA:
NR_002196
ALFRED:
LO158505Y
HuGE:
H19
Comparative Toxicogenomics Database:
283120
HGNC:
4713

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