guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?


Alternate Names:  None
Alternate Symbols:  GNG1
PharmGKB Accession Id: PA28790


Cytogenetic Location: chr7 : q21.3 - q21.3
GP mRNA Boundary: chr7 : 93535820 - 93540485
GP Gene Boundary: chr7 : 93525820 - 93543485
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. actions of nitric oxide in the heart - (BioCarta via Pathway Interaction Database)
  2. activation of camp-dependent protein kinase pka - (BioCarta via Pathway Interaction Database)
  3. activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor - (BioCarta via Pathway Interaction Database)
  4. aspirin blocks signaling pathway involved in platelet activation - (BioCarta via Pathway Interaction Database)
  5. attenuation of gpcr signaling - (BioCarta via Pathway Interaction Database)
  6. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  7. ccr3 signaling in eosinophils - (BioCarta via Pathway Interaction Database)
  8. chrebp regulation by carbohydrates and camp - (BioCarta via Pathway Interaction Database)
  9. corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
  10. cxcr4 signaling pathway - (BioCarta via Pathway Interaction Database)
  11. cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway - (BioCarta via Pathway Interaction Database)
  12. fmlp induced chemokine gene expression in hmc-1 cells - (BioCarta via Pathway Interaction Database)
  13. g-protein signaling through tubby proteins - (BioCarta via Pathway Interaction Database)
  14. how progesterone initiates the oocyte maturation - (BioCarta via Pathway Interaction Database)
  15. ion channels and their functional role in vascular endothelium - (BioCarta via Pathway Interaction Database)
  16. Olfactory Signaling Pathway - (Reactome via Pathway Interaction Database)
  17. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  18. pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase - (BioCarta via Pathway Interaction Database)
  19. regulation of ck1/cdk5 by type 1 glutamate receptors - (BioCarta via Pathway Interaction Database)
  20. regulation of spermatogenesis by crem - (BioCarta via Pathway Interaction Database)
  21. role of egf receptor transactivation by gpcrs in cardiac hypertrophy - (BioCarta via Pathway Interaction Database)
  22. role of ß-arrestins in the activation and targeting of map kinases - (BioCarta via Pathway Interaction Database)
  23. roles of ß arrestin dependent recruitment of src kinases in gpcr signaling - (BioCarta via Pathway Interaction Database)
  24. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  25. thrombin signaling and protease-activated receptors - (BioCarta via Pathway Interaction Database)
  26. Visual signal transduction: Rods - (Pathway Interaction Database NCI-Nature Curated)
  27. ß-arrestins in gpcr desensitization - (BioCarta via Pathway Interaction Database)


Entrez Gene:
UCSC Genome Browser:
RefSeq RNA:
RefSeq Protein:
RefSeq DNA:
GBG1_HUMAN (P63211)
Comparative Toxicogenomics Database:
HumanCyc Gene:

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