Gene:
GNB1
guanine nucleotide binding protein (G protein), beta polypeptide 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA28776

Details

Cytogenetic Location: chr1 : p36.33 - p36.33
GP mRNA Boundary: chr1 : 1716725 - 1822526
GP Gene Boundary: chr1 : 1713725 - 1832526
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.
  1. Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Representation of genes involved in nicotine effects in dopaminergic neurons.

External Pathways

Links to non-PharmGKB pathways.

  1. actions of nitric oxide in the heart - (BioCarta via Pathway Interaction Database)
  2. activation of camp-dependent protein kinase pka - (BioCarta via Pathway Interaction Database)
  3. activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor - (BioCarta via Pathway Interaction Database)
  4. aspirin blocks signaling pathway involved in platelet activation - (BioCarta via Pathway Interaction Database)
  5. attenuation of gpcr signaling - (BioCarta via Pathway Interaction Database)
  6. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  7. ccr3 signaling in eosinophils - (BioCarta via Pathway Interaction Database)
  8. chrebp regulation by carbohydrates and camp - (BioCarta via Pathway Interaction Database)
  9. corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
  10. cxcr4 signaling pathway - (BioCarta via Pathway Interaction Database)
  11. cystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway - (BioCarta via Pathway Interaction Database)
  12. fmlp induced chemokine gene expression in hmc-1 cells - (BioCarta via Pathway Interaction Database)
  13. g-protein signaling through tubby proteins - (BioCarta via Pathway Interaction Database)
  14. Hedgehog signaling events mediated by Gli proteins - (Pathway Interaction Database NCI-Nature Curated)
  15. how progesterone initiates the oocyte maturation - (BioCarta via Pathway Interaction Database)
  16. ion channels and their functional role in vascular endothelium - (BioCarta via Pathway Interaction Database)
  17. LPA receptor mediated events - (Pathway Interaction Database NCI-Nature Curated)
  18. Noncanonical Wnt signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  19. Nongenotropic Androgen signaling - (Pathway Interaction Database NCI-Nature Curated)
  20. Olfactory Signaling Pathway - (Reactome via Pathway Interaction Database)
  21. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  22. pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase - (BioCarta via Pathway Interaction Database)
  23. Plasma membrane estrogen receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  24. regulation of ck1/cdk5 by type 1 glutamate receptors - (BioCarta via Pathway Interaction Database)
  25. regulation of spermatogenesis by crem - (BioCarta via Pathway Interaction Database)
  26. role of egf receptor transactivation by gpcrs in cardiac hypertrophy - (BioCarta via Pathway Interaction Database)
  27. role of ß-arrestins in the activation and targeting of map kinases - (BioCarta via Pathway Interaction Database)
  28. roles of ß arrestin dependent recruitment of src kinases in gpcr signaling - (BioCarta via Pathway Interaction Database)
  29. Signaling events mediated by HDAC Class II - (Pathway Interaction Database NCI-Nature Curated)
  30. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  31. thrombin signaling and protease-activated receptors - (BioCarta via Pathway Interaction Database)
  32. Thromboxane A2 receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  33. visual signal transduction - (BioCarta via Pathway Interaction Database)
  34. Visual signal transduction: Rods - (Pathway Interaction Database NCI-Nature Curated)
  35. ß-arrestins in gpcr desensitization - (BioCarta via Pathway Interaction Database)

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCB3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCB4
No related diseases are available

LinkOuts

Entrez Gene:
2782
OMIM:
139380
UCSC Genome Browser:
NM_002074
RefSeq RNA:
NM_002074
RefSeq Protein:
NP_002065
RefSeq DNA:
AC_000044
AC_000133
NC_000001
NT_004350
NW_001838585
NW_921350
UniProtKB:
GBB1_HUMAN (P62873)
Ensembl:
ENSG00000078369
GenAtlas:
GNB1
GeneCard:
GNB1
MutDB:
GNB1
ALFRED:
LO047571Y
HuGE:
GNB1
Comparative Toxicogenomics Database:
2782
ModBase:
P62873
HumanCyc Gene:
HS01284
HGNC:
4396

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