Gene:
GEM
GTP binding protein overexpressed in skeletal muscle

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  kinase-inducible Ras-like protein
Alternate Symbols:  KIR
PharmGKB Accession Id: PA28645

Details

Cytogenetic Location: chr8 : q22.1 - q22.1
GP mRNA Boundary: chr8 : 95261481 - 95274547
GP Gene Boundary: chr8 : 95258481 - 95284547
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Publications related to GEM: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Sequential changes in gene expression profiles in breast cancers during treatment with the aromatase inhibitor, letrozole. The pharmacogenomics journal. 2010. Miller W R, et al. PubMed

LinkOuts

Entrez Gene:
2669
OMIM:
600164
UCSC Genome Browser:
NM_005261
RefSeq RNA:
NM_005261
NM_181702
RefSeq Protein:
NP_005252
NP_859053
RefSeq DNA:
AC_000051
AC_000140
NC_000008
NT_008046
NW_001839136
NW_923984
UniProtKB:
GEM_HUMAN (P55040)
Ensembl:
ENSG00000164949
GenAtlas:
GEM
GeneCard:
GEM
MutDB:
GEM
ALFRED:
LO023294U
HuGE:
GEM
Comparative Toxicogenomics Database:
2669
ModBase:
P55040
HumanCyc Gene:
HS09166
HGNC:
4234

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