Gene:
MAPK8
mitogen-activated protein kinase 8

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PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  JUN N-terminal kinase; PRKM8
Alternate Symbols:  JNK; JNK1; SAPK1
PharmGKB Accession Id: PA283

Details

Cytogenetic Location: chr10 : q11.22 - q11.22
GP mRNA Boundary: chr10 : 49609687 - 49643183
GP Gene Boundary: chr10 : 49599687 - 49646183
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.
  1. Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of tacrolimus and cyclosporine, as well as the candidate genes believed to interact with the two drugs.
  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. Activation of BIM and translocation to mitochondria - (Reactome via Pathway Interaction Database)
  2. Activation of BMF and translocation to mitochondria - (Reactome via Pathway Interaction Database)
  3. agrin in postsynaptic differentiation - (BioCarta via Pathway Interaction Database)
  4. Angiopoietin receptor Tie2-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  5. angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling - (BioCarta via Pathway Interaction Database)
  6. atm signaling pathway - (BioCarta via Pathway Interaction Database)
  7. bcr signaling pathway - (BioCarta via Pathway Interaction Database)
  8. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  9. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  10. bone remodeling - (BioCarta via Pathway Interaction Database)
  11. ceramide signaling pathway - (BioCarta via Pathway Interaction Database)
  12. Ceramide signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  13. Downstream signaling in naïve CD8+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  14. egf signaling pathway - (BioCarta via Pathway Interaction Database)
  15. Endothelins - (Pathway Interaction Database NCI-Nature Curated)
  16. Ephrin B reverse signaling - (Pathway Interaction Database NCI-Nature Curated)
  17. EPO signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  18. fas signaling pathway (cd95) - (BioCarta via Pathway Interaction Database)
  19. FAS signaling pathway (CD95) - (Pathway Interaction Database NCI-Nature Curated)
  20. fc epsilon receptor i signaling in mast cells - (BioCarta via Pathway Interaction Database)
  21. Glypican 3 network - (Pathway Interaction Database NCI-Nature Curated)
  22. hiv-1 nef: negative effector of fas and tnf - (BioCarta via Pathway Interaction Database)
  23. HIV-1 Nef: Negative effector of Fas and TNF-alpha - (Pathway Interaction Database NCI-Nature Curated)
  24. hypoxia and p53 in the cardiovascular system - (BioCarta via Pathway Interaction Database)
  25. igf-1 signaling pathway - (BioCarta via Pathway Interaction Database)
  26. IL1-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  27. il12 and stat4 dependent signaling pathway in th1 development - (BioCarta via Pathway Interaction Database)
  28. IL12 signaling mediated by STAT4 - (Pathway Interaction Database NCI-Nature Curated)
  29. IL2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  30. inhibition of cellular proliferation by gleevec - (BioCarta via Pathway Interaction Database)
  31. integrin signaling pathway - (BioCarta via Pathway Interaction Database)
  32. JNK signaling in the CD4+ TCR pathway - (Pathway Interaction Database NCI-Nature Curated)
  33. keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  34. links between pyk2 and map kinases - (BioCarta via Pathway Interaction Database)
  35. N-cadherin signaling events - (Pathway Interaction Database NCI-Nature Curated)
  36. nerve growth factor pathway (ngf) - (BioCarta via Pathway Interaction Database)
  37. nfat and hypertrophy of the heart - (BioCarta via Pathway Interaction Database)
  38. NRAGE signals death through JNK - (Reactome via Pathway Interaction Database)
  39. NRIF signals cell death from the nucleus - (Reactome via Pathway Interaction Database)
  40. Osteopontin-mediated events - (Pathway Interaction Database NCI-Nature Curated)
  41. pdgf signaling pathway - (BioCarta via Pathway Interaction Database)
  42. Reelin signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  43. Regulation of Androgen receptor activity - (Pathway Interaction Database NCI-Nature Curated)
  44. Regulation of glucocorticoid receptor - (Pathway Interaction Database NCI-Nature Curated)
  45. Retinoic acid receptors-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  46. Role of Calcineurin-dependent NFAT signaling in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  47. role of mal in rho-mediated activation of srf - (BioCarta via Pathway Interaction Database)
  48. S1P2 pathway - (Pathway Interaction Database NCI-Nature Curated)
  49. signal transduction through il1r - (BioCarta via Pathway Interaction Database)
  50. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  51. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
  52. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
  53. Syndecan-2-mediated signaling events - (Pathway Interaction Database NCI-Nature Curated)
  54. t cell receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  55. tnf/stress related signaling - (BioCarta via Pathway Interaction Database)
  56. toll-like receptor pathway - (BioCarta via Pathway Interaction Database)
  57. TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade - (Reactome via Pathway Interaction Database)
  58. TRAIL signaling pathway - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
sorafenib
No related diseases are available

Publications related to MAPK8: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. American journal of human genetics. 2009. Wang Kai, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science (New York, N.Y.). 2008. Sabio Guadalupe, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer research. 2004. Wilhelm Scott M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. The Journal of biological chemistry. 1997. Kroll J, et al. PubMed

LinkOuts

UniProtKB:
A1L4K2_HUMAN (A1L4K2)
MK08_HUMAN (P45983)
Ensembl:
ENSG00000107643
GenAtlas:
MAPK8
GeneCard:
MAPK8
MutDB:
MAPK8
ALFRED:
LO003424N
HuGE:
MAPK8
Comparative Toxicogenomics Database:
5599
ModBase:
P45983
HumanCyc Gene:
HS03015
HGNC:
6881

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