Gene:
FOXC1
forkhead box C1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  FKHL7; IRID1
Alternate Symbols:  ARA; FREAC3; IGDA; IHG1
PharmGKB Accession Id: PA28217

Details

Cytogenetic Location: chr6 : p25.3 - p25.3
GP mRNA Boundary: chr6 : 1610681 - 1614132
GP Gene Boundary: chr6 : 1600681 - 1617132
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Publications related to FOXC1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Homozygous nonsense mutation in the FOXE3 gene as a cause of congenital primary aphakia in humans. American journal of human genetics. 2006. Valleix Sophie, et al. PubMed

LinkOuts

Entrez Gene:
2296
OMIM:
601090
601631
602482
UCSC Genome Browser:
NM_001453
RefSeq RNA:
NM_001453
RefSeq Protein:
NP_001444
RefSeq DNA:
AC_000049
AC_000138
NC_000006
NG_009368
NT_007592
NW_001838972
NW_922984
UniProtKB:
FOXC1_HUMAN (Q12948)
Ensembl:
ENSG00000054598
GenAtlas:
FOXC1
GeneCard:
FOXC1
MutDB:
FOXC1
ALFRED:
LO185005T
HuGE:
FOXC1
Comparative Toxicogenomics Database:
2296
ModBase:
Q12948
HumanCyc Gene:
HS00672
HGNC:
3800

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