Gene:
EPHB4
EPH receptor B4

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  Tyro11
PharmGKB Accession Id: PA27827

Details

Cytogenetic Location: chr7 : q22.1 - q22.1
GP mRNA Boundary: chr7 : 100400187 - 100425143
GP Gene Boundary: chr7 : 100397187 - 100435143
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. EPHB forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. Ephrin B reverse signaling - (Pathway Interaction Database NCI-Nature Curated)

LinkOuts

Entrez Gene:
2050
OMIM:
600011
UCSC Genome Browser:
NM_004444
RefSeq RNA:
NM_004444
RefSeq Protein:
NP_004435
RefSeq DNA:
AC_000050
AC_000068
AC_000139
NC_000007
NT_007933
NT_079595
NW_001839065
NW_923574
HuGE:
EPHB4
Comparative Toxicogenomics Database:
2050
ModBase:
P54760
HumanCyc Gene:
HS02886
HGNC:
3395

Common Searches