Gene:
DTNBP1
dystrobrevin binding protein 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all DTNBP1 variant annotations

Variant?
(142)
Alternate Names ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs1011313 -22+4543A>G, 117+4543A>G, 15573432T>C, 15633432T>C, 171+4543A>G, 222+4543A>G, 34840A>G, 550+4543A>G
T > C
Intronic
No VIP available No Clinical Annotations available VA
rs2005976 -83+742G>A, 110+1516G>A, 15590802C>T, 15650802C>T, 161+742G>A, 17470G>A, 489+742G>A, 56+12243G>A
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs2619522 -232-1278T>G, 14623T>G, 15593649A>C, 15653649A>C, 385-1278T>G, 56+9396T>G, 57-1278T>G
A > C
Intronic
No VIP available CA VA
rs2619538 -1920T>A, -2109T>A, -2397T>A, 15605209A>T, 15665209A>T, 3063T>A
A > T
5' Flanking
No VIP available No Clinical Annotations available VA
rs2619539 113-5225G>C, 15560855C>G, 15620855C>G, 251-5225G>C, 305-5225G>C, 356-5225G>C, 47417G>C, 684-5225G>C
C > G
Intronic
No VIP available CA VA
rs3213207 -21-396A>G, 118-396A>G, 15568102T>C, 15628102T>C, 172-396A>G, 223-396A>G, 40170A>G, 551-396A>G
T > C
Intronic
No VIP available CA VA
rs742105 15513074C>T, 15573074C>T, 268+20216G>A, 406+20216G>A, 460+20216G>A, 511+20216G>A, 839+20216G>A, 95198G>A
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs760761 -83+412C>T, 110+1186C>T, 15591132G>A, 15651132G>A, 161+412C>T, 17140C>T, 489+412C>T, 56+11913C>T
G > A
Intronic
No VIP available CA VA
rs909706 -233+2174A>G, 15600871T>C, 15660871T>C, 246-119A>G, 56+2174A>G, 7401A>G
T > C
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 142

Overview

Alternate Names:  biogenesis of lysosomal organelles complex-1, subunit 8; dysbindin-1
Alternate Symbols:  BLOC1S8; DBND; Dysbindin; HPS7; My031
PharmGKB Accession Id: PA27512

Details

Cytogenetic Location: chr6 : p22.3 - p22.3
GP mRNA Boundary: chr6 : 15523032 - 15663289
GP Gene Boundary: chr6 : 15520032 - 15673289
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to DTNBP1: 10

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
No influence of DTNBP1 polymorphisms on the response to aripiprazole. Neuropsychobiology. 2010. Pae Chi-Un, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenetics and genomics. 2009. Zuo Lingjun, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Model-based gene selection shows engrailed 1 is associated with antipsychotic response. Pharmacogenetics and genomics. 2008. Webb Bradley Todd, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nature genetics. 2008. Allen Nicole C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. American journal of human genetics. 2008. Mill Jonathan, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
The dysbindin gene (DTNBP1) is associated with methamphetamine psychosis. Biological psychiatry. 2008. Kishimoto Makiko, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
A dysbindin risk haplotype associated with less severe manic-type symptoms in psychosis. Neuroscience letters. 2008. Corvin Aiden, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Effect of 5-haplotype of dysbindin gene (DTNBP1) polymorphisms for the susceptibility to bipolar I disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2007. Pae Chi-Un, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Identifying potential risk haplotypes for schizophrenia at the DTNBP1 locus in Han Chinese and Scottish populations. Molecular psychiatry. 2005. Li T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1). Biological psychiatry. 2005. Raybould Rachel, et al. PubMed

LinkOuts

UniProtKB:
A8MZA9_HUMAN (A8MZA9)
DTBP1_HUMAN (Q96EV8)
Ensembl:
ENSG00000047579
GenAtlas:
DTNBP1
GeneCard:
DTNBP1
MutDB:
DTNBP1
ALFRED:
LO000618P
HuGE:
DTNBP1
Comparative Toxicogenomics Database:
84062
ModBase:
Q96EV8
HumanCyc Gene:
HS12105
HGNC:
17328

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