Gene:
DNMT1
DNA (cytosine-5-)-methyltransferase 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  CXXC9; MCMT
PharmGKB Accession Id: PA27443

Details

Cytogenetic Location: chr19 : p13.2 - p13.2
GP mRNA Boundary: chr19 : 10244022 - 10305755
GP Gene Boundary: chr19 : 10241022 - 10315755
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Regulation of retinoblastoma protein - (Pathway Interaction Database NCI-Nature Curated)

Publications related to DNMT1: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. The pharmacogenomics journal. 2013. Del-Aguila J L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Perspectives on Epigenetics and Its Relevance to Adverse Drug Reactions. Clinical pharmacology and therapeutics. 2011. Kacevska M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene silencing in cancer in association with promoter hypermethylation. The New England journal of medicine. 2003. Herman James G, et al. PubMed

LinkOuts

Entrez Gene:
1786
OMIM:
126375
UCSC Genome Browser:
NM_001379
RefSeq RNA:
NM_001130823
NM_001379
RefSeq Protein:
NP_001124295
NP_001370
RefSeq DNA:
AC_000062
AC_000151
NC_000019
NT_011295
NW_001838483
NW_927195
UniProtKB:
DNMT1_HUMAN (P26358)
Ensembl:
ENSG00000130816
GenAtlas:
DNMT1
GeneCard:
DNMT1
MutDB:
DNMT1
ALFRED:
LO179023W
HuGE:
DNMT1
Comparative Toxicogenomics Database:
1786
ModBase:
P26358
HumanCyc Gene:
HS05448
HGNC:
2976

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