Gene:
CTNNB1
catenin (cadherin-associated protein), beta 1, 88kDa

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  CTNNB
Alternate Symbols:  armadillo; beta-catenin
PharmGKB Accession Id: PA27013

Details

Cytogenetic Location: chr3 : p22.1 - p22.1
GP mRNA Boundary: chr3 : 41240942 - 41281939
GP Gene Boundary: chr3 : 41230942 - 41284939
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Celecoxib Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of celecoxib and candidate genes interacting with celecoxib and involved in the regulation of cell cycle, apoptosis and angiogenesis by celecoxib.

External Pathways

Links to non-PharmGKB pathways.

  1. Apoptotic cleavage of cell adhesion proteins - (Reactome via Pathway Interaction Database)
  2. Arf6 trafficking events - (Pathway Interaction Database NCI-Nature Curated)
  3. Beta-catenin phosphorylation cascade - (Reactome via Pathway Interaction Database)
  4. Canonical Wnt signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  5. cell to cell adhesion signaling - (BioCarta via Pathway Interaction Database)
  6. Coregulation of Androgen receptor activity - (Pathway Interaction Database NCI-Nature Curated)
  7. Degradation of beta-catenin by the destruction complex - (Reactome via Pathway Interaction Database)
  8. E-cadherin signaling events - (Pathway Interaction Database NCI-Nature Curated)
  9. E-cadherin signaling in keratinocytes - (Pathway Interaction Database NCI-Nature Curated)
  10. E-cadherin signaling in the nascent adherens junction - (Pathway Interaction Database NCI-Nature Curated)
  11. FoxO family signaling - (Pathway Interaction Database NCI-Nature Curated)
  12. inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages - (BioCarta via Pathway Interaction Database)
  13. multi-step regulation of transcription by pitx2 - (BioCarta via Pathway Interaction Database)
  14. N-cadherin signaling events - (Pathway Interaction Database NCI-Nature Curated)
  15. Presenilin action in Notch and Wnt signaling - (Pathway Interaction Database NCI-Nature Curated)
  16. segmentation clock - (BioCarta via Pathway Interaction Database)
  17. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  18. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  19. Stabilization and expansion of the E-cadherin adherens junction - (Pathway Interaction Database NCI-Nature Curated)
  20. TGF-beta receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  21. trefoil factors initiate mucosal healing - (BioCarta via Pathway Interaction Database)
  22. wnt signaling pathway - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
celecoxib
No related diseases are available

Publications related to CTNNB1: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. The pharmacogenomics journal. 2010. Ho-Pun-Cheung A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Targeted cancer therapies in the twenty-first century: lessons from imatinib. Clinical pharmacology and therapeutics. 2010. Stegmeier F, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science (New York, N.Y.). 2007. Major Michael B, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Targeting the beta-catenin/APC pathway: a novel mechanism to explain the cyclooxygenase-2-independent anticarcinogenic effects of celecoxib in human colon carcinoma cells. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2005. Maier Thorsten J├╝rgen, et al. PubMed

LinkOuts

UniProtKB:
CTNA2_HUMAN (P26232)
CTNB1_HUMAN (P35222)
Ensembl:
ENSG00000168036
GenAtlas:
CTNNB1
GeneCard:
CTNNB1
MutDB:
CTNNB1
ALFRED:
LO062873A
HuGE:
CTNNB1
Comparative Toxicogenomics Database:
1499
ModBase:
P35222
HumanCyc Gene:
HS09683
HGNC:
2514

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