Gene:
CRK
v-crk sarcoma virus CT10 oncogene homolog (avian)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  v-crk sarcoma virus CT10 oncogene homolog (avian)
Alternate Symbols:  None
PharmGKB Accession Id: PA26880

Details

Cytogenetic Location: chr17 : p13.3 - p13.3
GP mRNA Boundary: chr17 : 1325440 - 1359544
GP Gene Boundary: chr17 : 1322440 - 1369544
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. VEGF Signaling Pathway
    Model endothelial cell displaying genes of the VEGF signalling pathway and the sites at which bevacizumab, sorafenib, sunitinib, brivanib and cilengitide are known to act.

External Pathways

Links to non-PharmGKB pathways.

  1. Angiopoietin receptor Tie2-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. ARMS-mediated activation - (Reactome via Pathway Interaction Database)
  3. E-cadherin signaling in the nascent adherens junction - (Pathway Interaction Database NCI-Nature Curated)
  4. Endothelins - (Pathway Interaction Database NCI-Nature Curated)
  5. EPHA forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  6. EPHB forward signaling - (Pathway Interaction Database NCI-Nature Curated)
  7. IGF1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  8. Insulin Pathway - (Pathway Interaction Database NCI-Nature Curated)
  9. LPA receptor mediated events - (Pathway Interaction Database NCI-Nature Curated)
  10. Nectin adhesion pathway - (Pathway Interaction Database NCI-Nature Curated)
  11. p130Cas linkage to MAPK signaling for integrins - (Reactome via Pathway Interaction Database)
  12. Paxillin-dependent events mediated by a4b1 - (Pathway Interaction Database NCI-Nature Curated)
  13. Paxillin-independent events mediated by a4b1 and a4b7 - (Pathway Interaction Database NCI-Nature Curated)
  14. PDGFR-alpha signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  15. Signal attenuation - (Reactome via Pathway Interaction Database)
  16. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  17. Signaling events mediated by PTP1B - (Pathway Interaction Database NCI-Nature Curated)
  18. Signaling events regulated by Ret tyrosine kinase - (Pathway Interaction Database NCI-Nature Curated)
  19. VEGFR3 signaling in lymphatic endothelium - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

No related diseases are available

Publications related to CRK: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. The Journal of biological chemistry. 1999. Larsson H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation. Oncogene. 1999. Klint P, et al. PubMed

LinkOuts

Entrez Gene:
1398
OMIM:
164762
UCSC Genome Browser:
NM_005206
RefSeq RNA:
NM_005206
NM_016823
RefSeq Protein:
NP_005197
NP_058431
RefSeq DNA:
AC_000060
AC_000149
NC_000017
NT_010718
NW_001838403
NW_926584
UniProtKB:
CRK_HUMAN (P46108)
Q96GA9_HUMAN (Q96GA9)
Ensembl:
ENSG00000167193
GenAtlas:
CRK
GeneCard:
CRK
MutDB:
CRK
ALFRED:
LO043490U
HuGE:
CRK
Comparative Toxicogenomics Database:
1398
ModBase:
P46108
HumanCyc Gene:
HS09523
HGNC:
2362

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