Gene:
CRHR2
corticotropin releasing hormone receptor 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all CRHR2 variant annotations

Variant?
(142)
Alternate Names ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs2267715 187+5444C>T, 229+5444C>T, 28633C>T, 30706087G>A, 30716087G>A, 310+5444C>T
G > A
Intronic
No VIP available No Clinical Annotations available VA
rs2270007 30689972G>C, 30699972G>C, 44748C>G, 789+217C>G, 828+217C>G, 831+217C>G, 912+217C>G
G > C
Intronic
No VIP available CA VA
rs2284220 187+3428C>T, 229+3428C>T, 26617C>T, 30708103G>A, 30718103G>A, 310+3428C>T
G > A
Intronic
No VIP available CA VA
rs255100 -260-8T>A, 15812T>A, 30718908A>T, 30728908A>T, 91-8T>A
A > T
Intronic
No VIP available No Clinical Annotations available VA
rs73294475 30691596T>C, 30701596T>C, 43124A>G, 716+176A>G, 755+176A>G, 758+176A>G, 839+176A>G
T > C
Intronic
No VIP available CA VA
rs7793837 -166-546T>A, 17943T>A, 184+2030T>A, 30716777A>T, 30726777A>T, CRHR2: Intronic, downstream of exon beta 1b
A > T
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 142

Overview

Alternate Names:  None
Alternate Symbols:  CRF-RB; CRF2; HM-CRF
PharmGKB Accession Id: PA26875

Details

Cytogenetic Location: chr7 : p14.3 - p14.3
GP mRNA Boundary: chr7 : 30691559 - 30739719
GP Gene Boundary: chr7 : 30688559 - 30749719
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
    Simplified diagram of the actions of corticotropin releasing factor(CRH) and related hormones which regulate the release of glcocorticoids via the hypothalamic pituitary adrenal axis.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
citalopram
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
salbutamol

Curated Information ?

Publications related to CRHR2: 9

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
A genome-wide association study of bronchodilator response in Latinos implicates rare variants. The Journal of allergy and clinical immunology. 2013. Drake Katherine A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of antidepressant drugs: current clinical practice and future directions. Pharmacogenomics. 2012. Narasimhan Sneha, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pathway based analysis of genotypes in relation to alcohol dependence. The pharmacogenomics journal. 2011. Reimers M A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Influence of gene-gene interactions on response to albuterol therapy. Pharmacogenomics. 2011. Moore Paul E. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. Pharmacogenetics and genomics. 2008. Poon Audrey H, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. Journal of affective disorders. 2007. Papiol Sergi, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Candidate genes for antidepressant response to selective serotonin reuptake inhibitors. Neuropsychiatric disease and treatment. 2005. Lotrich Francis E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in corticotropin-releasing factor receptor (CRFR) 1- and CRFR2-null mice, and regulation by glucocorticoids. Endocrinology. 2004. Chen Alon, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Expression of corticotropin releasing hormone receptors type I and type II mRNA in suicide victims and controls. Molecular psychiatry. 2001. Hiroi N, et al. PubMed

LinkOuts

UniProtKB:
CRFR2_HUMAN (Q13324)
Ensembl:
ENSG00000106113
GenAtlas:
CRHR2
GeneCard:
CRHR2
MutDB:
CRHR2
ALFRED:
LO005451P
HuGE:
CRHR2
Comparative Toxicogenomics Database:
1395
ModBase:
Q13324
HumanCyc Gene:
HS02864
IUPHAR Receptor:
CRF2 (213)
HGNC:
2358

Common Searches