Gene:
CREBBP
CREB binding protein

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PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  RSTS
Alternate Symbols:  CBP; KAT3A; RTS
PharmGKB Accession Id: PA26866

Details

Cytogenetic Location: chr16 : p13.3 - p13.3
GP mRNA Boundary: chr16 : 3775055 - 3930121
GP Gene Boundary: chr16 : 3772055 - 3940121
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway (Peripheral Tissue), Pharmacodynamics
    Genes involved in mediating glucocorticoid effects at the tissue level in the CNS and in the peripheral tissues including heart, lung, vasculatrue and guts.

External Pathways

Links to non-PharmGKB pathways.

  1. acetylation and deacetylation of rela in nucleus - (BioCarta via Pathway Interaction Database)
  2. activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor - (BioCarta via Pathway Interaction Database)
  3. Canonical Wnt signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  4. carm1 and regulation of the estrogen receptor - (BioCarta via Pathway Interaction Database)
  5. Class I PI3K signaling events mediated by Akt - (Pathway Interaction Database NCI-Nature Curated)
  6. control of gene expression by vitamin d receptor - (BioCarta via Pathway Interaction Database)
  7. control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) - (BioCarta via Pathway Interaction Database)
  8. FOXA1 transcription factor network - (Pathway Interaction Database NCI-Nature Curated)
  9. FOXM1 transcription factor network - (Pathway Interaction Database NCI-Nature Curated)
  10. FoxO family signaling - (Pathway Interaction Database NCI-Nature Curated)
  11. granzyme a mediated apoptosis pathway - (BioCarta via Pathway Interaction Database)
  12. Hedgehog signaling events mediated by Gli proteins - (Pathway Interaction Database NCI-Nature Curated)
  13. HIF-1-alpha transcription factor network - (Pathway Interaction Database NCI-Nature Curated)
  14. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  15. il-7 signal transduction - (BioCarta via Pathway Interaction Database)
  16. IL12 signaling mediated by STAT4 - (Pathway Interaction Database NCI-Nature Curated)
  17. inhibition of huntingtons disease neurodegeneration by histone deacetylase inhibitors - (BioCarta via Pathway Interaction Database)
  18. multi-step regulation of transcription by pitx2 - (BioCarta via Pathway Interaction Database)
  19. nfat and hypertrophy of the heart - (BioCarta via Pathway Interaction Database)
  20. nfkb activation by nontypeable hemophilus influenzae - (BioCarta via Pathway Interaction Database)
  21. Notch-HLH transcription pathway - (Reactome via Pathway Interaction Database)
  22. pelp1 modulation of estrogen receptor activity - (BioCarta via Pathway Interaction Database)
  23. Presenilin action in Notch and Wnt signaling - (Pathway Interaction Database NCI-Nature Curated)
  24. Regulation of Androgen receptor activity - (Pathway Interaction Database NCI-Nature Curated)
  25. Regulation of glucocorticoid receptor - (Pathway Interaction Database NCI-Nature Curated)
  26. Regulation of nuclear SMAD2/3 signaling - (Pathway Interaction Database NCI-Nature Curated)
  27. Regulation of retinoblastoma protein - (Pathway Interaction Database NCI-Nature Curated)
  28. regulation of transcriptional activity by pml - (BioCarta via Pathway Interaction Database)
  29. Retinoic acid receptors-mediated signaling - (Pathway Interaction Database NCI-Nature Curated)
  30. Role of Calcineurin-dependent NFAT signaling in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  31. role of ppar-gamma coactivators in obesity and thermogenesis - (BioCarta via Pathway Interaction Database)
  32. Signaling events mediated by HDAC Class I - (Pathway Interaction Database NCI-Nature Curated)
  33. Signaling events mediated by HDAC Class III - (Pathway Interaction Database NCI-Nature Curated)
  34. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
  35. tgf beta signaling pathway - (BioCarta via Pathway Interaction Database)
  36. the information processing pathway at the ifn beta enhancer - (BioCarta via Pathway Interaction Database)
  37. transcription regulation by methyltransferase of carm1 - (BioCarta via Pathway Interaction Database)
  38. wnt signaling pathway - (BioCarta via Pathway Interaction Database)

Publications related to CREBBP: 6

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of disease-modifying antirheumatic drugs in rheumatoid arthritis: towards personalized medicine. Pharmacogenomics. 2013. Umićević Mirkov Maša, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature genetics. 2012. the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Key pathways are frequently mutated in high risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Blood. 2011. Zhang Jinghui, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Histone acetyl transferases as emerging drug targets. Drug discovery today. 2009. Dekker Frank J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. Science (New York, N.Y.). 2007. Jung Joonil, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. The Journal of biological chemistry. 2003. Litterst Claudia M, et al. PubMed

LinkOuts

Entrez Gene:
1387
OMIM:
180849
600140
UCSC Genome Browser:
NM_004380
RefSeq RNA:
NM_001079846
NM_004380
RefSeq Protein:
NP_001073315
NP_004371
RefSeq DNA:
AC_000059
AC_000148
NC_000016
NG_009873
NT_010393
NW_001838341
NW_926018
UniProtKB:
Q4LE28_HUMAN (Q4LE28)
CBP_HUMAN (Q92793)
Ensembl:
ENSG00000005339
GenAtlas:
CREBBP
GeneCard:
CREBBP
MutDB:
CREBBP
ALFRED:
LO054100K
HuGE:
CREBBP
Comparative Toxicogenomics Database:
1387
ModBase:
Q92793
HumanCyc Gene:
HS00138
HGNC:
2348

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