Gene:
CLOCK
clock circadian regulator

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs1522113 3671654G>A, 439-1799C>T, 56331771G>A
G > A
Intronic
No VIP available CA VA
rs1801260 *213T>C, 3641252A>G, 56301369A>G
A > G
3' UTR
No VIP available No Clinical Annotations available VA
rs34897046 3665248G>C, 56325365G>C, 623C>G, Ser208Cys
G > C
Missense
Ser208Cys
No VIP available No Clinical Annotations available VA
rs3736544 1764T>C, 3649875A>G, 56309992A>G, Asn588=
A > G
Synonymous
Asn588Asn
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  None
Alternate Symbols:  KAT13D; KIAA0334; bHLHe8
PharmGKB Accession Id: PA26609

Details

Cytogenetic Location: chr4 : q12 - q12
GP mRNA Boundary: chr4 : 56298660 - 56412997
GP Gene Boundary: chr4 : 56295660 - 56422997
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Circadian rhythm pathway - (Pathway Interaction Database NCI-Nature Curated)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
lithium
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
salbutamol

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Asthma
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Bipolar Disorder

Publications related to CLOCK: 6

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A genome-wide association study of bronchodilator response in asthmatics. The pharmacogenomics journal. 2013. Duan Q L, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Functional genetic variation in the Rev-Erbalpha pathway and lithium response in the treatment of bipolar disorder. Genes, brain, and behavior. 2011. McCarthy M J, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Pharmacogenetics of lithium response in bipolar disorder. Pharmacogenomics. 2010. McCarthy Michael J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. The American journal of clinical nutrition. 2009. Garaulet Marta, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2007. Benedetti Francesco, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of selective serotonin reuptake inhibitor response: a 6-month follow-up. Pharmacogenetics. 2004. Serretti Alessandro, et al. PubMed

LinkOuts

Entrez Gene:
9575
OMIM:
601851
UCSC Genome Browser:
NM_004898
RefSeq RNA:
NM_004898
RefSeq Protein:
NP_004889
RefSeq DNA:
AC_000047
AC_000136
NC_000004
NT_022853
NW_001838913
NW_922162
UniProtKB:
CLOCK_HUMAN (O15516)
Ensembl:
ENSG00000134852
GenAtlas:
CLOCK
GeneCard:
CLOCK
MutDB:
CLOCK
ALFRED:
LO076017V
HuGE:
CLOCK
Comparative Toxicogenomics Database:
9575
ModBase:
O15516
HumanCyc Gene:
HS05922
HGNC:
2082

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