Gene:
TPP1
tripeptidyl peptidase I

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  CLN2; SCAR7; TPP I
Alternate Symbols:  None
PharmGKB Accession Id: PA26600

Details

Cytogenetic Location: chr11 : p15.4 - p15.4
GP mRNA Boundary: chr11 : 6633997 - 6640692
GP Gene Boundary: chr11 : 6630997 - 6650692
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Publications related to TPP1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood. 2003. Ross Mary E, et al. PubMed

LinkOuts

Entrez Gene:
1200
OMIM:
204500
607998
UCSC Genome Browser:
NM_000391
RefSeq RNA:
NM_000391
RefSeq Protein:
NP_000382
RefSeq DNA:
AC_000054
AC_000143
NC_000011
NG_008653
NT_009237
NW_001838021
NW_925006
UniProtKB:
TPP1_HUMAN (O14773)
Ensembl:
ENSG00000166340
GenAtlas:
TPP1
GeneCard:
TPP1
MutDB:
TPP1
ALFRED:
LO177222V
HuGE:
TPP1
Comparative Toxicogenomics Database:
1200
ModBase:
O14773
HumanCyc Gene:
HS09379
HGNC:
2073

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