Gene:
CHI3L1
chitinase 3-like 1 (cartilage glycoprotein-39)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  None
Alternate Symbols:  GP39; YKL40
PharmGKB Accession Id: PA26463

Details

Cytogenetic Location: chr1 : q32.1 - q32.1
GP mRNA Boundary: chr1 : 203148059 - 203155922
GP Gene Boundary: chr1 : 203145059 - 203165922
Strand: minus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

Publications related to CHI3L1: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. American journal of respiratory and critical care medicine. 2009. Rogers Angela J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism. Biological psychiatry. 2008. Yang Mao Sheng, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. The New England journal of medicine. 2008. Ober Carole, et al. PubMed

LinkOuts

Entrez Gene:
1116
OMIM:
181500
601525
611960
UCSC Genome Browser:
NM_001276
RefSeq RNA:
NM_001276
RefSeq Protein:
NP_001267
RefSeq DNA:
AC_000044
AC_000133
NC_000001
NG_013056
NT_004487
NW_001838533
NW_926128
UniProtKB:
CH3L1_HUMAN (P36222)
Ensembl:
ENSG00000133048
GenAtlas:
CHI3L1
GeneCard:
CHI3L1
MutDB:
CHI3L1
ALFRED:
LO027146U
HuGE:
CHI3L1
Comparative Toxicogenomics Database:
1116
ModBase:
P36222
HumanCyc Gene:
HS05723
HGNC:
1932

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