Gene:
NOD2
nucleotide-binding oligomerization domain containing 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all NOD2 variant annotations

Variant?
(142)
Alternate Names ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs17221417 13533C>G, 4353781C>G, 50739582C>G, 541-2184C>G
C > G
Intronic
No VIP available CA VA
rs2066844 19877C>T, 2104C>T, 4360125C>T, 50745926C>T
C > T
Missense
Arg702Trp
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 142

Overview

Alternate Names:  CARD15; IBD1; NLR family, CARD domain containing 2; NOD-like receptor C2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
Alternate Symbols:  BLAU; CD; CLR16.3; NLRC2; PSORAS1
PharmGKB Accession Id: PA26074

Details

Cytogenetic Location: chr16 : q12.1 - q12.1
GP mRNA Boundary: chr16 : 50731050 - 50766987
GP Gene Boundary: chr16 : 50721050 - 50769987
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Canonical NF-kappaB pathway - (Pathway Interaction Database NCI-Nature Curated)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
tacrolimus

Curated Information ?

Publications related to NOD2: 7

No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Increased Hospital Stay and Allograft Disfunction in Renal Transplanted Patients with CYP2C19 AA Variant in SNP RS4244285. Drug metabolism and disposition: the biological fate of chemicals. 2012. Boso Virginia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Innate immune gene polymorphisms in tuberculosis. Infection and immunity. 2012. Azad Abul K, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. American journal of human genetics. 2010. Ritchie Marylyn D, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genomewide association study of leprosy. The New England journal of medicine. 2009. Zhang Fu-Ren, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. American journal of human genetics. 2009. Holmans Peter, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS genetics. 2007. Libioulle C├ęcile, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NOD2/CARD15 does not influence response to infliximab in Crohn's disease. Gastroenterology. 2002. Vermeire Severine, et al. PubMed

LinkOuts

Entrez Gene:
64127
OMIM:
181000
186580
266600
605956
607507
609464
UCSC Genome Browser:
NM_022162
RefSeq RNA:
NM_022162
RefSeq Protein:
NP_071445
MutDB:
CARD15
ALFRED:
LO037440S
HuGE:
CARD15
Comparative Toxicogenomics Database:
64127
HumanCyc Gene:
HS09526
HGNC:
5331

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