Gene:
CALM1
calmodulin 1 (phosphorylase kinase, delta)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  prepro-calmodulin 1
Alternate Symbols:  CAMI; DD132; PHKD
PharmGKB Accession Id: PA26035

Details

Cytogenetic Location: chr14 : q32.11 - q32.11
GP mRNA Boundary: chr14 : 90863327 - 90874619
GP Gene Boundary: chr14 : 90853327 - 90877619
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  2. Calcineurin-regulated NFAT-dependent transcription in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  3. Calcium signaling in the CD4+ TCR pathway - (Pathway Interaction Database NCI-Nature Curated)
  4. CaM pathway - (Reactome via Pathway Interaction Database)
  5. CaMK IV-mediated phosphorylation of CREB - (Reactome via Pathway Interaction Database)
  6. Cellular roles of Anthrax toxin - (Pathway Interaction Database NCI-Nature Curated)
  7. DARPP-32 events - (Reactome via Pathway Interaction Database)
  8. Downstream signaling in naïve CD8+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  9. eNOS activation - (Reactome via Pathway Interaction Database)
  10. Further platelet releasate - (Reactome via Pathway Interaction Database)
  11. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  12. IL2 signaling events mediated by PI3K - (Pathway Interaction Database NCI-Nature Curated)
  13. Insulin-mediated glucose transport - (Pathway Interaction Database NCI-Nature Curated)
  14. Lissencephaly gene (LIS1) in neuronal migration and development - (Pathway Interaction Database NCI-Nature Curated)
  15. N-cadherin signaling events - (Pathway Interaction Database NCI-Nature Curated)
  16. p38 MAPK signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  17. Phosphorylase kinase activates glycogen phosphorylase - (Reactome via Pathway Interaction Database)
  18. PKA activation - (Reactome via Pathway Interaction Database)
  19. Regulation of cytoplasmic and nuclear SMAD2/3 signaling - (Pathway Interaction Database NCI-Nature Curated)
  20. Role of Calcineurin-dependent NFAT signaling in lymphocytes - (Pathway Interaction Database NCI-Nature Curated)
  21. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  22. VEGFR1 specific signals - (Pathway Interaction Database NCI-Nature Curated)

Publications related to CALM1: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood. 2003. Ross Mary E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

Entrez Gene:
801
OMIM:
114180
UCSC Genome Browser:
NM_006888
RefSeq RNA:
NM_001166106
NM_006888
RefSeq Protein:
NP_001159578
NP_008819
MutDB:
CALM1
ALFRED:
LO037828C
HuGE:
CALM1
Comparative Toxicogenomics Database:
801
HumanCyc Gene:
HS07128
HGNC:
1442

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