nitric oxide synthase 1 (neuronal)
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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).
|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Symbols: ||nNOS|
|PharmGKB Accession Id:||PA252|
|Cytogenetic Location:||chr12 : q24.22 - q24.31|
|GP mRNA Boundary†:||chr12 : 117645947 - 117799607|
|GP Gene Boundary†:||chr12 : 117642947 - 117809607|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
Representation of the candidate genes involved in adverse effects of doxorubicin in a stylized cardiomyocyte.
Doxorubicin Pathway, Pharmacokinetics
Diagrammatic representation of the transport and metabolism of doxorubicin.
Links to non-PharmGKB pathways.
Publications related to NOS1: 4
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenetics and genomics. 2010. Thorn Caroline F, et al.|
||Candidate genes for antidepressant response to selective serotonin reuptake inhibitors. Neuropsychiatric disease and treatment. 2005. Lotrich Francis E, et al.|
||Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation. 2003. Pacher Pál, et al.|
||Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice. The Journal of pharmacology and experimental therapeutics. 2000. Weinstein D M, et al.|