ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
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PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).
|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Symbols: ||None|
|PharmGKB Accession Id:||PA25130|
|Cytogenetic Location:||chr1 : p13.2 - p13.2|
|GP mRNA Boundary†:||chr1 : 111991743 - 112004540|
|GP Gene Boundary†:||chr1 : 111981743 - 112007540|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Doxorubicin Pathway (Cardiomyocyte Cell), Pharmacodynamics
Representation of the candidate genes involved in adverse effects of doxorubicin in a stylized cardiomyocyte.
Links to non-PharmGKB pathways.
Publications related to ATP5F1: 2
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||New developments in anthracycline-induced cardiotoxicity. Current medicinal chemistry. 2009. Mordente A, et al.|
||Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proceedings of the National Academy of Sciences of the United States of America. 1988. Olson R D, et al.|