ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.
A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).
|PGx Test||Variants Assayed||Related Drugs?|
|Alternate Names:||calcium pump 1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1|
|Alternate Symbols: ||SERCA1|
|PharmGKB Accession Id:||PA25105|
|Cytogenetic Location:||chr16 : p12.1 - p11.2|
|GP mRNA Boundary†:||chr16 : 28889809 - 28915830|
|GP Gene Boundary†:||chr16 : 28879809 - 28918830|
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
Antiarrhythmic Pathway, Pharmacodynamics
Pharmacodynamic pathway of antiarrhythmic drugs in a stylized cardiac myocyte.
Celecoxib Pathway, Pharmacodynamics
Stylized cell depicting the mechanism of action of celecoxib and candidate genes interacting with celecoxib and involved in the regulation of cell cycle, apoptosis and angiogenesis by celecoxib.
Links to non-PharmGKB pathways.
PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.
Publications related to ATP2A1: 2
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Molecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase gene. The Journal of biological chemistry. 1988. Lytton J, et al.|
||Two Ca2+ ATPase genes: homologies and mechanistic implications of deduced amino acid sequences. Cell. 1986. Brandl C J, et al.|