Gene:
AKR1C1
aldo-keto reductase family 1, member C1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

Overview

Alternate Names:  dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase
Alternate Symbols:  DD1; DDH; HAKRC; MBAB
PharmGKB Accession Id: PA24677

Details

Cytogenetic Location: chr10 : p15.1 - p14
GP mRNA Boundary: chr10 : 5005454 - 5020158
GP Gene Boundary: chr10 : 4995454 - 5023158
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

Entrez Gene:
1645
OMIM:
600449
UCSC Genome Browser:
NM_001353
RefSeq RNA:
NM_001353
RefSeq Protein:
NP_001344
RefSeq DNA:
AC_000142
NC_000010
NT_008705
NW_001837930
NW_921365
UniProtKB:
AK1C1_HUMAN (Q04828)
Ensembl:
ENSG00000187134
GenAtlas:
AKR1C1
GeneCard:
AKR1C1
MutDB:
AKR1C1
ALFRED:
LO209118V
HuGE:
AKR1C1
Comparative Toxicogenomics Database:
1645
ModBase:
Q04828
HumanCyc Gene:
HS10741
HGNC:
384

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