Gene:
ADORA2A
adenosine A2a receptor

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this . To report a drug label with PGx, click here.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(138)
Alternate Names / Tag SNPs ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs2236624 1012-489A>G, 24836024T>C, 333-527T>C, 4226593T>C, 574+1936A>G, ADORA2A: g.4226593T>C
T > C
Intronic
No VIP available CA VA
rs2267076 24830595T>C, 332+891T>C, 4221164T>C, 575-2193A>G, ADORA2A: g.4221164T>C
T > C
Intronic
No VIP available CA VA
rs2298383 -275+1797C>T, 2235A>A, 24825511C>T, 4216080C>T, ADORA2A: g.4216080C>T
C > T
Intronic
No VIP available No Clinical Annotations available VA
rs3032740 1285+221_1285+222insAAAAA, 24835040_24835041insTTTTT, 333-1511_333-1510insTTTTT, 4225609_4225610insTTTTT, 574+2919_574+2920insAAAAA
- > TTTTT
Not Available
No VIP available No Clinical Annotations available VA
rs35320474 *453_*454insT, 1011+49_1011+50insA, 24837910_24837911insT, 2592C>Tins, 4228479_4228480insT, 574+49_574+50insA, ADORA2A:2592T/-, Exon 5; 2592 Ins/DelT
- > T
Not Available
No VIP available CA VA
rs3761422 -274-2427T>C, 1398+208A>G, 24826672T>C, 4217241T>C, ADORA2A: g.4217241T>C
T > C
Intronic
No VIP available CA VA
rs5751876 1011+659A>G, 1083T>C, 24837301T>C, 4227870T>C, 574+659A>G, ADORA2A:1083T>C, ADORA2A:1976T>C, Tyr361=
T > C
Synonymous
Tyr361Tyr
No VIP available CA VA
rs5760410 153617G>A, 24815406G>A, 4205975G>A, ADORA2A: g.4205975G>A
G > A
Not Available
No VIP available No Clinical Annotations available VA
rs5996696 -274-1477A>C, 24827622A>C, 4218191A>C, 748-92T>G
A > C
Intronic
No VIP available No Clinical Annotations available VA
rs71651683 -274-246C>T, 24828853C>T, 4219422C>T, 575-451G>A
C > T
Intronic
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 138

Overview

Alternate Names:  None
Alternate Symbols:  RDC8
PharmGKB Accession Id: PA24584

Details

Cytogenetic Location: chr22 : q11.23 - q11.23
GP mRNA Boundary: chr22 : 24823530 - 24838325
GP Gene Boundary: chr22 : 24813530 - 24841325
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. NGF-independant TRKA activation - (Reactome via Pathway Interaction Database)
No related genes are available

Curated Information ?

Curated Information ?

Publications related to ADORA2A: 21

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of disease-modifying antirheumatic drugs in rheumatoid arthritis: towards personalized medicine. Pharmacogenomics. 2013. Umićević Mirkov Maša, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
PharmGKB summary: caffeine pathway. Pharmacogenetics and genomics. 2012. Thorn Caroline F, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
ADORA2A Gene Variation, Caffeine, and Emotional Processing: A Multi-level Interaction on Startle Reflex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2011. Domschke Katharina, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Coffee, ADORA2A, and CYP1A2: the caffeine connection in Parkinson's disease. European journal of neurology : the official journal of the European Federation of Neurological Societies. 2011. Popat R A, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Methylxanthines and pain. Handbook of experimental pharmacology. 2011. Sawynok Jana. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2010. Rogers Peter J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms. Journal of Alzheimer's disease : JAD. 2010. Prediger Rui D S. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate. Arthritis and rheumatism. 2009. Varani Katia, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians. Pharmacogenetics and genomics. 2009. Sharma Shruti, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008. Childs Emma, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist. Science (New York, N.Y.). 2008. Jaakola Veli-Pekka, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Coffee, caffeine-related genes, and Parkinson's disease: a case-control study. Movement disorders : official journal of the Movement Disorder Society. 2008. Facheris Maurizio F, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Polymorphisms within the adenosine receptor 2a gene are associated with adverse events in RA patients treated with MTX. Rheumatology (Oxford, England). 2008. Hider S L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. Pharmacogenetics and genomics. 2007. Riksen Niels P, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. The American journal of clinical nutrition. 2007. Cornelis Marilyn C, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clinical pharmacology and therapeutics. 2007. Rétey J V, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Association between A2a receptor gene polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003. Alsene Karen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis and rheumatism. 2003. Montesinos M Carmen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Update on caffeine consumption, disposition and action. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2002. Mandel H G. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Molecular action of methotrexate in inflammatory diseases. Arthritis research. 2002. Chan Edwin S L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis. Arthritis and rheumatism. 2000. Montesinos M C, et al. PubMed

LinkOuts

Entrez Gene:
135
OMIM:
102776
UCSC Genome Browser:
NM_000675
RefSeq RNA:
NM_000675
RefSeq Protein:
NP_000666
RefSeq DNA:
AC_000065
AC_000154
NC_000022
NT_011520
NW_001838745
NW_927628
HuGE:
ADORA2A
Comparative Toxicogenomics Database:
135
ModBase:
P29274
HumanCyc Gene:
HS05169
IUPHAR Receptor:
A2A (19)
HGNC:
263

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