adenosine kinase

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?


Alternate Names:  adenosine 5'-phosphotransferase
Alternate Symbols:  AK
PharmGKB Accession Id: PA24579


Cytogenetic Location: chr10 : q22.2 - q22.2
GP mRNA Boundary: chr10 : 75910943 - 76469061
GP Gene Boundary: chr10 : 75900943 - 76472061
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Abacavir Pathway, Pharmacokinetics/Pharmacodynamics
    Schematic representation of abacavir metabolism and mechanism of action. The potential mechanism of an abacavir hypersensitivity reaction is also shown.

External Pathways

Links to non-PharmGKB pathways.

  1. Deoxyribonucleotide salvage - (Reactome via Pathway Interaction Database)
  2. Phosphorylation of cytosolic nucleosides by adenosine kinase - (Reactome via Pathway Interaction Database)
  3. Ribonucleotide salvage - (Reactome via Pathway Interaction Database)

Publications related to ADK: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation. Biochemical pharmacology. 1999. Hatse S, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Identification and isolation on a large scale of guanylate kinase from human erythrocytes. Effects of monophosphate nucleotides of purine analogs. Biochemical pharmacology. 1971. Agarwal R P, et al. PubMed


ADK_HUMAN (P55263)
Comparative Toxicogenomics Database:
HumanCyc Gene:

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