PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.
PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.
PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
|
Variant?
(build 132) |
Alternate Names ? | Drugs ? | Alleles ? | Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs1229984 | ADH1B*2, ADH1B: Arg47His, c.143A>G, g.24787040T>C, g.8254A>G, p.His48Arg | T > C | Missense | His48Arg | ||
| rs1229985 | G/A | Not Available | ||||
| rs17033 | T/C | Not Available | ||||
| rs2018417 | C > A | Not Available | Ala222Ala | |||
| rs2066702 | ADH1B*3, ADH1B: Arg396Cys, c.1108C>T, g.18556C>T, g.24776738G>A, p.Arg370Cys | G > A | Missense | Arg370Cys |
Overview
| Alternate Names: | ADH, beta subunit; alcohol dehydrogenase 1B; alcohol dehydrogenase 1B (class I), beta polypeptide; alcohol dehydrogenase 2; alcohol dehydrogenase 2 (class I), beta polypeptide; alcohol dehydrogenase IB (class I), beta polypeptide; alcohol dehydrogenase subunit beta; aldehyde reductase; class I alcohol dehydrogenase, beta subunit |
|---|---|
| Alternate Symbols: | ADH2; DKFZp686C06125 |
| PharmGKB Accession Id: | PA24571 |
Details
| Cytogenetic Location: | chr4 : q23 - q23 |
|---|---|
| GP mRNA Boundary†: | chr4 : 100227527 - 100242572 |
| GP Gene Boundary†: | chr4 : 100224527 - 100252572 |
| Strand: | minus |
| Product Name: | ADH, beta subunit, alcohol dehydrogenase 1B (class I), beta polypeptide, alcohol dehydrogenase 2, alcohol dehydrogenase 2 (class I), beta polypeptide, aldehyde reductase |
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
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Cyclophosphamide Pathway, Pharmacodynamics
Model non-tissue-specific cancer cell displaying genes which may be involved in the cyclophosphamide pathway.
External Pathways
Links to non-PharmGKB pathways.
Datasets
Downloads
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LinkOuts
- UniProtKB:
- ADH1B_HUMAN (P00325)
- Ensembl:
- ENSG00000196616
- GenAtlas:
- ADH1B
- GeneCard:
- GC04M100226 (125)
- SOURCE:
- ADH1B
- MutDB:
- ADH1B
Common Searches
Non-Curated Publications
A list of non-curated publications that mention this gene is available.