Gene:
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide

PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.

PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.

PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

Variant?
(build 132) 		Alternate Names ? Drugs ? Alleles ?
(+ chr strand) 		Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs1229967
G > T
G > C
 Not Available
No VIP available No Clinical Annotations available VA
rs1229976
C > T
 Not Available
No VIP available No Clinical Annotations available VA
rs1826909
C > T
 Not Available
No VIP available No Clinical Annotations available VA
rs2276332
A > C
 Not Available
No VIP available No Clinical Annotations available VA
rs6811453
G > T
G > C
G > A
 Not Available
No VIP available No Clinical Annotations available VA
rs931635
A > G
 Not Available
VIP No Clinical Annotations available No Variant Annotations available
rs975833 ADH1A^SNP11, c.3790-6213G>C, c.829-303C>G, g.24749460G>C
G > C
 Not Available
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP build 132

Overview

Alternate Names:  ADH, alpha subunit; alcohol dehydrogenase 1; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase 1A; alcohol dehydrogenase subunit alpha; aldehyde reductase; class I alcohol dehydrogenase, alpha subunit
Alternate Symbols:  ADH1
PharmGKB Accession Id: PA24570

Details

Cytogenetic Location: chr4 : q23 - q23
GP mRNA Boundary†: chr4 : 100197524 - 100212142
GP Gene Boundary†: chr4 : 100194524 - 100222142
Strand: minus
Product Name: No data available
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Celecoxib Pathway, Pharmacokinetics
  1. Cyclophosphamide Pathway, Pharmacodynamics
    Model non-tissue-specific cancer cell displaying genes which may be involved in the cyclophosphamide pathway.

External Pathways

Links to non-PharmGKB pathways.

  1. Ethanol is oxidized by NAD+ to form acetaldehyde, NADH, and H+ - (Reactome via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA VIP No VIP available
ethanol

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Alcoholism

Publications related to ADH1A: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
Celecoxib pathways: pharmacokinetics and pharmacodynamics. Pharmacogenetics and genomics. 2012. Gong Li, et al. [Article:22336956@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans. Human molecular genetics. 2007. Luo Xingguang, et al. [Article:17185388@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. American journal of human genetics. 2006. Luo Xingguang, et al. [Article:16685648@PubMed]
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available VIP No VIP available
Three-dimensional structures of the three human class I alcohol dehydrogenases. Protein science : a publication of the Protein Society. 2001. Niederhut M S, et al. [Article:11274460@PubMed]
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