Gene:
GNAI2
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

PharmGKB contains no dosing guidelines for this gene. To report known dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB contains no drug labels with pharmacogenomic information for this gene. To report a drug label with PGx, click here.

PharmGKB contains no clinical annotations for this gene. To report clinical variants, click here.

PharmGKB contains no genetic tests for this gene. To report genetic tests, click here.

Overview

Alternate Names:  GTP-binding regulatory protein Gi alpha-2 chain
Alternate Symbols:  GIP
PharmGKB Accession Id: PA24347

Details

Cytogenetic Location: chr3 : p21.31 - p21.31
GP mRNA Boundary†: chr3 : 50273647 - 50296786
GP Gene Boundary†: chr3 : 50263647 - 50299786
Strand: plus
† The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Simplified pharmacodynamic pathway of drug action on beta 2 adrenergic receptor in a stylized airway cell.
  1. Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Effects of antiplatelet drugs on platelet aggregation pathway.
  1. Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
    Genes involved in serotonin synthesis, release, reuptake, and in mediation of the antidepressant effect of selective serotonin reuptake inhibitors (SSRI) in human brain.

External Pathways

Links to non-PharmGKB pathways.

  1. Thromboxane A2 receptor signaling - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ADCY1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ADCY2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ADCY3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
F2R
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
F2RL3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
HTR1A
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
HTR1B
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
HTR1D
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
HTR1E
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
HTR1F
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
P2RY1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
P2RY12
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCB1
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
PLCG2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
TBXA2R
No related diseases are available

Publications related to GNAI2: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Molecular mechanisms of beta(2)-adrenergic receptor function, response, and regulation. The Journal of allergy and clinical immunology. 2006. Johnson Malcolm. PubMed

LinkOuts

Entrez Gene:
2771
OMIM:
139360
192605
UCSC Genome Browser:
NM_002070
RefSeq RNA:
NM_001166425
NM_002070
RefSeq Protein:
NP_001159897
NP_002061
RefSeq DNA:
AC_000046
AC_000135
NC_000003
NG_016002
NT_022517
NW_001838877
NW_921651
UniProtKB:
B3KP24_HUMAN (B3KP24)
B3KX51_HUMAN (B3KX51)
B4DYA0_HUMAN (B4DYA0)
GNAI2_HUMAN (P04899)
Ensembl:
ENSG00000114353
GenAtlas:
GNAI2
GeneCard:
GNAI2
MutDB:
GNAI2
ALFRED:
LO068398I
HuGE:
GNAI2
Comparative Toxicogenomics Database:
2771
ModBase:
P04899
HumanCyc Gene:
HS03759
HGNC:
4385

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