Gene:
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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This is a non-comprehensive list of genetic tests with pharmacogenetics relevance, typically submitted by the manufacturer and manually curated by PharmGKB. The information listed is provided for educational purposes only and does not constitute an endorsement of any listed test or manufacturer.

A more complete listing of genetic tests is found at the Genetic Testing Registry (GTR).

PGx Test Variants Assayed Related Drugs?

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all PTGS1 variant annotations

Variant?
(142)
Alternate Names ? Drugs ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs10306114 -1140A>G, -287A>G, -762A>G, -842A>G, -890A>G, -920A>G, 125132522A>G, 4294A>G, 54297054A>G, A-842G
A > G
5' Flanking
No VIP available No Clinical Annotations available VA
rs10306135 -204-2512A>T, -233-2483A>T, -262A>T, 125137695A>T, 175-2512A>T, 20-2483A>T, 54302227A>T, 623-2483A>T, 9467A>T, 95-2483A>T
A > T
Intronic
No VIP available No Clinical Annotations available VA
rs12353214 125161870C>T, 54326402C>T
C > T
Not Available
No VIP available No Clinical Annotations available VA
rs1236913 -276T>C, -277T>C, -306T>C, 102T>C, 125133479T>C, 22T>C, 328T>C, 5251T>C, 54298011T>C, C22T, Trp8Arg
T > C
5' UTR
Trp8Arg
No VIP available No Clinical Annotations available VA
rs3842787 -248C>T, -249C>T, -278C>T, 125133507C>T, 130C>T, 356C>T, 50C>T, 5279C>T, 54298039C>T, C>T, PTGS1: P17L, Pro17Leu
C > T
5' UTR
Pro17Leu
No VIP available No Clinical Annotations available VA
rs5788 1167C>A, 125143792C>A, 15564C>A, 312C>A, 495C>A, 54308324C>A, 564C>A, 639C>A, 690C>A, C644A, Gly104=, Gly165=, Gly188=, Gly213=
C > A
Synonymous
Gly188Gly
No VIP available No Clinical Annotations available VA
rs5789 1237C>A, 125143973C>A, 15745C>A, 382C>A, 54308505C>A, 565C>A, 634C>A, 709C>A, 760C>A, C714A, Leu128Met, Leu189Met, Leu212Met, Leu237Met
C > A
Missense
Leu212Met
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 142

Overview

Alternate Names:  None
Alternate Symbols:  COX1; PGHS-1; PTGHS
PharmGKB Accession Id: PA24346

Details

Cytogenetic Location: chr9 : q32 - q33.3
GP mRNA Boundary: chr9 : 125133229 - 125157981
GP Gene Boundary: chr9 : 125123229 - 125160981
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Acetaminophen Pathway, Pharmacokinetics
    Stylized diagram showing acetaminophen metabolism and transport in the liver and kidney.
  1. Celecoxib Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of celecoxib and candidate genes interacting with celecoxib and involved in the regulation of cell cycle, apoptosis and angiogenesis by celecoxib.
  1. Etoposide Pathway, Pharmacokinetics/Pharmacodynamics
    Etoposide cellular disposition and effects.
  1. Ibuprofen Pathway, Pharmacodynamics
    Stylized cell depicting the mechanism of action of ibuprofen (IBU).
  1. Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Effects of antiplatelet drugs on platelet aggregation pathway.

External Pathways

Links to non-PharmGKB pathways.

  1. aspirin blocks signaling pathway involved in platelet activation - (BioCarta via Pathway Interaction Database)
  2. basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression - (BioCarta via Pathway Interaction Database)
  3. eicosanoid metabolism - (BioCarta via Pathway Interaction Database)
  4. mechanism of acetaminophen activity and toxicity - (BioCarta via Pathway Interaction Database)
No related genes are available

Curated Information ?

Curated Information ?

Publications related to PTGS1: 26

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetic insights into migraine treatment in children. Pharmacogenomics. 2014. Gentile Giovanna, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction. International journal of cardiology. 2012. Verschuren Jeffrey J W, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1. Pharmacogenetics and genomics. 2012. Liu Wen, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of drugs withdrawn from the market. Pharmacogenomics. 2012. Zhang Wei, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Genetic polymorphisms and the cardiovascular risk of non-steroidal anti-inflammatory drugs. The American journal of cardiology. 2010. St Germaine Christine G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics in cardiovascular antithrombotic therapy. Journal of the American College of Cardiology. 2009. Marín Francisco, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
COX-1 and vascular disease. Clinical pharmacology and therapeutics. 2009. Vanhoutte P M. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The genetics of antiplatelet drug resistance. Clinical genetics. 2009. Feher G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Antiplatelet drug 'resistance'. Part 1: mechanisms and clinical measurements. Nature reviews. Cardiology. 2009. Sweeny Joseph M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Cyclooxygenase-1 haplotype C50T/A-842G does not affect platelet response to aspirin. Thrombosis and haemostasis. 2009. Pettinella Caterina, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. Genomics. 2009. Yoshida Tetsuro, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study. Clinical pharmacology and therapeutics. 2008. Lee C R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of platelet responsiveness to aspirin. Pharmacogenomics. 2007. Faraday Nauder, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007. Ito Noriyuki, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. Pharmacogenomics. 2007. Li Qing, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. Circulation. 2007. Faraday Nauder, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation. 2007. Maree Andrew O, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Dose-related efficacy of aspirin after coronary surgery in patients With Pl(A2) polymorphism (NCT00262275). The Annals of thoracic surgery. 2007. Lim Eric, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The pharmacogenetics of antiplatelet drugs. Current opinion in investigational drugs (London, England : 2000). 2007. Marín Francisco, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenetics and genomics. 2007. Lee Craig R, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology. 2006. Fries Susanne, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer research. 2006. Daikoku Takiko, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients. Thrombosis and haemostasis. 2006. Lepäntalo Aino, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Cyclooxygenase-1 haplotype modulates platelet response to aspirin. Journal of thrombosis and haemostasis : JTH. 2005. Maree A O, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Free radical intermediates of phenytoin and related teratogens. Prostaglandin H synthase-catalyzed bioactivation, electron paramagnetic resonance spectrometry, and photochemical product analysis. The Journal of biological chemistry. 1998. Parman T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. The Journal of biological chemistry. 1996. Smith W L, et al. PubMed

LinkOuts

Entrez Gene:
5742
OMIM:
176805
UCSC Genome Browser:
NM_000962
RefSeq RNA:
NM_000962
NM_080591
RefSeq Protein:
NP_000953
NP_542158
RefSeq DNA:
AC_000052
AC_000141
NC_000009
NT_008470
NW_001839239
NW_924573
UniProtKB:
PGH1_HUMAN (P23219)
Ensembl:
ENSG00000095303
GenAtlas:
PTGS1
GeneCard:
PTGS1
MutDB:
PTGS1
ALFRED:
LO026365W
HuGE:
PTGS1
Comparative Toxicogenomics Database:
5742
ModBase:
P23219
HumanCyc Gene:
HS01815
HGNC:
9604

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